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Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

Research Project

Project/Area Number 23592683
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionJikei University School of Medicine (2013-2014)
Showa University (2011-2012)

Principal Investigator

DOHI KENJI  東京慈恵会医科大学, 医学部, 准教授 (20301509)

Co-Investigator(Kenkyū-buntansha) SHIODA Seiji  昭和大学, 医学部, 教授 (80102375)
ARUGA Tohru  昭和大学, 医学部, 教授 (40266086)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords頭部外傷 / アルツハイマー病 / 神経炎症 / 脳浮腫 / ミトコンドリア / 酸化ストレス / 水素水 / 抗酸化療法 / 神経外傷 / 治療 / 予防法 / フリーラジカル / 高次脳機能障害 / 機能水 / 国際情報交流
Outline of Final Research Achievements

Acute Traumatic brain injury (TBI) can transform into a chronic condition and be a risk factor for Alzheimer's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (mHW) to alter the acute changes after TBI in mice. We found that mHW reversed CCI-induced edema, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but attenuated that increase by day 7, reversed changes seen in the protein levels of aquaporin-4, HIF-1, MMP-2, and MMP-9, but not for amyloid beta peptide 1-40 or 1-42. Treatment with mHW also reversed the increase seen 4 h after CCI in gene expression related to oxidation/carbohydrate metabolism, cytokine release, leukocyte or cell migration, cytokine transport, ATP and nucleotide binding. These results suggest that it could be an easily administered, highly effective treatment for TBI.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury2014

    • Author(s)
      Dohi K, Kraemer BC, Erickson MA, McMillan PJ, Kovac A, Flachbartova Z, Hansen KM, Shah GN, Sheibani N, Salameh T, Banks WA
    • Journal Title

      plos one

      Volume: 24(9) Issue: 9 Pages: e108034-e108034

    • DOI

      10.1371/journal.pone.0108034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Therapeutic time window for edaravone treatment of traumatic brain injury in mice.2013

    • Author(s)
      Miyamoto K, Ohtaki H, Dohi K, Tsumuraya T, Song D, Kiriyama K, Satoh K, Shimizu A, Aruga T, Shioda S
    • Journal Title

      Biomed Res Int.

      Volume: 2013 Pages: 379206-379206

    • DOI

      10.1155/2013/379206

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 水素水の外傷前飲用が頭部外傷後におけるグリア活性化とサイトカイン誘導に与える効果について2015

    • Author(s)
      土肥 謙二 ,佐藤 和恵 ,小川 武希
    • Organizer
      第38回日本脳神経外傷学会
    • Place of Presentation
      あわぎんホール:徳島
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hydrogen in drinking water reduces brain edema after traumatic brain2014

    • Author(s)
      kenji dohi, Kazuyuki Miyamito, Kazue Satoh, Takeki Ogawa
    • Organizer
      Free Radical Biology and Medicine’s Annual Meeting 2014
    • Place of Presentation
      Seattle,WA.U.S.A
    • Year and Date
      2014-11-19 – 2014-11-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経機能予後改善を目的とした水素付加機能水の効果について2014

    • Author(s)
      土肥 謙二 ,佐藤 和恵 ,小川 武希
    • Organizer
      第42回日本救急医学会総会
    • Place of Presentation
      福岡国際会議場:福岡
    • Year and Date
      2014-10-28 – 2014-10-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経機能予後改善を目的とした水素水の効果について2014

    • Author(s)
      土肥 謙二 ,宮本 和幸 ,佐藤 和恵 ,小川 武希
    • Organizer
      第67回日本酸化ストレス学会
    • Place of Presentation
      同志社大学今出川キャンパス:京都
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 外傷性脳損傷における水素水(mHW)の効果について2014

    • Author(s)
      土肥謙二
    • Organizer
      日本集中治療学会総会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Hydrogen in drinking water reduces brain edema after traumatic brain injury in mice2014

    • Author(s)
      Kenji Dohi
    • Organizer
      国際フリーラジカル会議
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス頭部外傷モデルにおける水素水の脳浮腫抑制機構2013

    • Author(s)
      土肥謙二、宮本和幸、大滝博和、塩田清二、有賀徹
    • Organizer
      第36回日本脳神経外傷学会
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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