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Bone marrow stromal cells and thymosin beta 4 attenuate septic organ failure

Research Project

Project/Area Number 23592688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionFujita Health University

Principal Investigator

KANO Hideki  藤田保健衛生大学, 医学部, 准教授 (90340231)

Co-Investigator(Kenkyū-buntansha) TAKEYAMA Naoshi  藤田保健衛生大学, 医学部救命救急医学講座, 教授 (00155053)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords骨随前駆細胞 / VEGF / CXCL8 / 敗血症 / NETs / 免疫染色 / cell-free DNA / 間葉系幹細胞 / thymosin 4
Research Abstract

Recent evidence suggests that vascular maintenance during sepsis is thought to important mechanisms to repair endothelial damage. This repair is mediated by recruitment from bone marrow of endothelial progenitor cells (EPCs). Therefore we were interested in whether EPCs, measured by FACS, are mobilized during sepsis and if this mobilization is related to clinical outcome. We showed that the appearance of CD34+ cells in the blood of patients with sepsis reduced compared to healthy controls. Plasma levels of growth factor VEGF and chemokine CXCL8 are significantly higher in septic patients compared to healthy volunteers. These results suggest that sepsis would induce bone marrow hypo-responsiveness to cytokines.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results)

  • [Journal Article] Downregulation of neutrophil derived cell-free DNA in sepsis2013

    • Author(s)
      Tomino A、Huq MA、Nakagawa T、Takeyama N
    • Journal Title

      J Clin Lab Invest Updates

      Volume: 1 Pages: 3-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis2013

    • Author(s)
      Gando S、Saitoh D、Ogura H、Fujishima S、Takeyama N 14
    • Journal Title

      Crit Care

      Volume: 17

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 敗血症性ショック患者におけるT細胞機能障害2014

    • Author(s)
      武山直志、富野敦稔、波柴尉充、安藤雅規、5
    • Organizer
      第29回日本ショック学会
    • Place of Presentation
      松山
    • Related Report
      2013 Final Research Report
  • [Presentation] Altered T cell repertoire diversity in septic shock patients2014

    • Author(s)
      Takeyama N、Tomino A、Hashiba M、3
    • Organizer
      31^<st> International symposium on Intensive Care and Emergency medicine 2014
    • Place of Presentation
      Brussels
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本における敗血症(セプシス)の疫学:海外との比較2013

    • Author(s)
      小倉裕司、丸藤哲、斎藤大蔵、武山直志15
    • Organizer
      第26回日本外科感染症学会総会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Neutrophil extracellular trap formation capacity is altered in neutrophil from septic patients2013

    • Author(s)
      Huq MA、Takeyama N、8
    • Organizer
      The 7^<th> Asian conference on emergency medicine
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Epidemiology of severe sepsis in Japanese intensive care units : A prospective multicenter study2013

    • Author(s)
      Ogura H、Gando S、Saito D、Fujishima S、Takeyama N, 14
    • Organizer
      The 7^<th> Asian conference on emergency medicine
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] Sepsis alters the extracellular bacterial killing capacity of neutrophil2013

    • Author(s)
      Huq MA, Hirakawa A, Hattori T, Takeyama N, Kano H, 6
    • Organizer
      Seventh Mediterranean Emergency Medicine Congress
    • Place of Presentation
      Marseille
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 敗血症治療と病態のupdate2013

    • Author(s)
      武山直志
    • Organizer
      第28回日本救命医療学会総会
    • Place of Presentation
      久留米
    • Related Report
      2013 Final Research Report
  • [Presentation] 敗血症治療と病態の最前線2013

    • Author(s)
      武山直志
    • Organizer
      第7回北海道DIC学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症敗血症の集中治療:日本救急医学会sepsis registry解析結果からの展望2013

    • Author(s)
      丸藤哲、斎藤大蔵、藤島清太郎、真弓俊彦、武山直志、14
    • Organizer
      第40回日本集中治療医学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] Neutrophil extracellular trap formation capacity is altered in neutrophil from septic patients2013

    • Author(s)
      Huq MA, Hirakawa A, Hattori T, Kano H, Miyabe H, Tomino A, Gocho T, Ando M, Nakagawa T, and Takeyama N
    • Organizer
      The 7th Asian conference on emergency medicine
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] 外科的感染症とその制御法2012

    • Author(s)
      武山直志
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎
    • Related Report
      2013 Final Research Report
  • [Presentation] Quality of care and mortality of severe sepsis and septic shock in Japan2012

    • Author(s)
      Fujishima S、Gando S、Saito D、Takeyama N、14
    • Organizer
      ATS 2012 International Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] 敗血症性ショックに対するPMX施行開始時期と治療効果に関する他施設共同前向き研究2012

    • Author(s)
      武山直志
    • Organizer
      第13回エンドトキシン血症救命治療研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 敗血症2011

    • Author(s)
      武山直志
    • Organizer
      第1回東海感染症研究会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Final Research Report
  • [Presentation] 敗血症病態とその治療;急性血液浄化療法を中心に2011

    • Author(s)
      武山直志
    • Organizer
      第4回岐阜外傷カンファレンス
    • Place of Presentation
      岐阜
    • Related Report
      2013 Final Research Report
  • [Presentation] 敗血症:侵襲反応の破綻をいかに回復させるか2011

    • Author(s)
      武山直志
    • Organizer
      第19回日本集中治療医学会東海北陸地方会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Final Research Report
  • [Presentation] 高度外傷、敗血症時の血漿中circulating free-DNAの動的変化

    • Author(s)
      武山直志、加納秀記、中村智之、2
    • Organizer
      第40回日本救急医学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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