| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Recent evidence suggests that vascular maintenance during sepsis is thought to important mechanisms to repair endothelial damage. This repair is mediated by recruitment from bone marrow of endothelial progenitor cells (EPCs). Therefore we were interested in whether EPCs, measured by FACS, are mobilized during sepsis and if this mobilization is related to clinical outcome. We showed that the appearance of CD34+ cells in the blood of patients with sepsis reduced compared to healthy controls. Plasma levels of growth factor VEGF and chemokine CXCL8 are significantly higher in septic patients compared to healthy volunteers. These results suggest that sepsis would induce bone marrow hypo-responsiveness to cytokines.
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