| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Fgf23 is a phosphaturic factor which is secreted from osteocytes in bone. Fgf23 plays a central role for phosphate metabolism as demonstrated by elevated serum levels of Fgf23 in hypophosphatemic diseases. Post-transcriptional modification of Fgf23 is extensively studied, however mechanisms of transcriptional regulation of Fgf23 are not fully understood. In this study, we demonstrated that serum calcium regulates Fgf23 expression by Dickopf-1-mediated inhibition of Wnt/beta-catenin signaling in bone. This result will provide the possibilities of a new therapy for hypophosphatemic diseases by using anti-Dickpof-1 antibody.
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