| Project/Area Number |
23592698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ABE Makoto 大阪大学, 歯学研究科(研究院), 助教 (40448105)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Syunji 和歌山県立医科大学, 医学研究科, 助教 (50275351)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 顎関節 / 発生 / 転写因子 / TRPS1 / ノックアウトマウス / 下顎 / GATA / Trps1 / コラーゲン / TRPS |
|---|
| Research Abstract |
Patients of Trichorhinophalangeal syndrome (TRPS) exhibit characteristic facial appearance which includes pear-shape nose and micrognathia (small jaw). In most of the case, TRPS results from mutation in the gene, TRPS1. In order to understand the mechanisms of the appearance of the facial phenotype in the TRPS patients, we examined the craniofacial development of the Trps1 knockout mice. The knockout mice were examined during its embryonic stage since this KO pups die soon after its birth. Trps1 was expressed throughout the embryonic stages of temporomandibular development. KO mice showed defects in mandibular bone development, especially in its proximal region. Articular disc, upper and lower joint cavities were never formed in the mutants. Also, the cellular proliferation at the condylar cartilage was significantly decreased.
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