Study of cerebral cortical mechanisms possibly responsible for jaw-movement disorders

• Project/Area Number: 23592699
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: YOSHIDA Atsushi 大阪大学, 歯学研究科(研究院), 教授 (90201855)
• Co-Investigator(Kenkyū-buntansha): KATO Takafumi 大阪大学, 大学院歯学研究科, 講師 (50367520) ; ONO Takahiro 大阪大学, 大学院歯学研究科, 准教授 (30204241) ; MORITANI Masayuki 森ノ宮医療大学, 保健医療学部, 教授 (80303981)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 顎運動 / 三叉神経運動核 / 運動ニューロン / 大脳皮質 / 脳 / 神経 / 解剖 / 歯学 / 咀嚼 / 顎 / 抑制性ニューロン / 頤

Research Abstract

Electrical stimulation of the primary somatosensory cortex and the lateral part of the prefrontal cortex (insular cortex) as well as the lateral part of the agranular cortex induced jaw-movements which are specific for the cortical location stimulated. However, stimulation of the medial part of the agranular cortex did not induce any jaw-movements. These cortical areas sent direct projections to the trigeminal sensory nuclear complex and the reticular formation around the trigeminal motor nucleus both of which include excitatory and/or inhibitory premotoneurons. Note that such premotoneurons were also found in the solitary tract nucleus.
These results may indicate that several indirect projections from the cerebral cortical areas to the trigeminal motor nucleus via its premotoneurons are involved in the induction of the characteristic jaw-movements, and the jaw-movement disorders are attributed to the disorders of the indirect projection systems from the cerebral cortical areas.

Research Products

• [Journal Article] 2014 Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis (medullary dorsal horn) and other lower brainstem areas in rats (2014)
  • Author(s): Akhter F, Haque T, Sato F, Kato T, Ohara H, Fujio T, Tsutsumi K, Uchino K, Ssssle BJ, Yoshida A
  • Journal Title: Neuroscience Volume: 266 Pages: 23-37
  • DOI: 10.1016/j.neuroscience.2014.01.046
• [Journal Article] Jaw-opening and -closing premotoneurons in the nucleus of the solitary tract making contacts with laryngeal and pharyngeal afferent terminals in rats (2013)
  • Author(s): Oka A, Yamamoto M, Takeda R, Ohara H, Sato F, Akhter F, Haque T, Kato T, Sessle BJ, Takada K, Yoshida A
  • Journal Title: Brain Res Volume: 1540 Pages: 48-63
  • DOI: 10.1016/j.brainres.2013.10.009
  • Peer Reviewed
• [Journal Article] Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats (2013)
  • Author(s): Sato F, Akhter F, Haque T, Kato T, Takeda R, Nagase Y, Sessle BJ, Yoshida A
  • Journal Title: Neuroscience Volume: 233 Pages: 9-27
  • DOI: 10.1016/j.neuroscience.2012.12.024
• [Journal Article] Cortical area inducing chewing-like rhythmical jaw movements and its connections with thalamic nuclei in guinea pigs. (2012)
  • Author(s): Isogai F, Kato T, Fujimoto M, Toi S, Oka A, Adachi T, Maeda Y, Morimoto T, Yoshida A, Masuda Y
  • Journal Title: Neurosci Res Volume: 74 Issue: 3-4 Pages: 239-247
  • DOI: 10.1016/j.neures.2012.10.009
  • Peer Reviewed
• [Journal Article] γ-aminobutyric acid-, glycine-, and glutamate-immunopositive boutons on mesencephalic trigeminal neurons that innervate jaw-closing muscle spindles in the rat: ultrastructure and development. (2012)
  • Author(s): Paik SK, Kwak MK, Bae JY, Yi HW, Yoshida A, Ahn DK, Bae YC
  • Journal Title: J Comp Neurol Volume: 520 Issue: 15 Pages: 3414-3427
  • DOI: 10.1002/cne.23110
  • Peer Reviewed
• [Journal Article] Somatotopic direct projections from orofacial areas of secondary somatosensory cortex to trigeminal sensory nuclear complex in rats. (2012)
  • Author(s): T Haque, F Akhter, T Kato, F Sato, R Takeda, K Higashiyama, M Moritani, Y-C Bae, BJ Sessle, A Yoshida
  • Journal Title: Neuroscience Volume: 219 Pages: 214-233
  • DOI: 10.1016/j.neuroscience.2012.05.065
  • Peer Reviewed
• [Journal Article] Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats (2012)
  • Author(s): A Tomita, T Kato, F Sato, T Haque, A Oka, M Yamamoto, T Ono, Y- C Bae, Y Maeda, BJ Sessle, A Yoshida
  • Journal Title: Neuroscience Volume: 200 Pages: 166-185
  • DOI: 10.1016/j.neuroscience.2011.10.048
• [Journal Article] Development of GABA-, glycine-, and glutamate- immunopositive boutons onto rat jaw-opening motoneurons (2012)
  • Author(s): SK Paik, WK Kwak, JY Bae, YK Na, SY Park, HW Yi, DK Ahn, OP Ottersen, A Yoshida, YC Bae
  • Journal Title: J Comp Neurol Volume: 520 Issue: 6 Pages: 1212-1226
  • DOI: 10.1002/cne.22771
  • Peer Reviewed
• [Presentation] 開口筋運動前ニューロンと閉口筋運動前ニューロンのラット孤束核内での機能局在 (2013)
  • Author(s): 岡綾香、武田理恵子、大原春香、佐藤文彦、加藤隆史、山城隆、吉田篤
  • Organizer: 日本口腔科学会近畿地方部会2013
  • Place of Presentation: 大阪歯科大学創立100周年記念館、大阪市
  • Year and Date: 2013-12-07
• [Presentation] Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats (2013)
  • Author(s): F Sato, T Hque, A Oka, K Higashiyama, K Yamada, F Akhter, H Ohara, T Fujio, M Yamamoto, K Uchino, T Kato, A Yoshida
  • Organizer: 日本神経科学会Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
  • Year and Date: 2013-06-20
• [Presentation] Differences in projections from the primary and secondary sonatosensory cortex to the trigeminal sensory nuclear complex in the rat (2013)
  • Author(s): T Haque, F Sato, A Oka, R Takeda, F Akhter, M. Higashiyama, T Kato, A Yoshida
  • Organizer: 日本神経科学会Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
  • Year and Date: 2013-06-20
• [Presentation] 三叉神経感覚核ならひに大脳皮質一次およひ二次体性感覚野から背側視床への投射の検討 (2013)
  • Author(s): 武田理恵子、大原春香、岡綾香、佐藤文彦、加藤隆史、山城隆、吉田篤
  • Organizer: 第7回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本歯科大学新潟生命歯学部・新潟大学駅南キャンパスときめいと、新潟市
• [Presentation] Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis and connections of the dorsal peduncular cortex with the insular cortex in rats (2013)
  • Author(s): Tahsinul Haque, Fatema Akhter, Fumihiko Sato, Takafumi Kato, Atsushi Yoshida
  • Organizer: 第7回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本歯科大学新潟生命歯学部・新潟大学駅南キャンパスときめいと、新潟市
• [Presentation] DIRECT PROJECTIONS FROM THE PREFRONTAL CORTEX TO OROFACIAL PAIN-RELATED LOWER BRAINSTEM AREAS, ESPECIALLY TO THE TRIGEMINAL CAUDAL SUBNUCLEUS, IN RATS (2013)
  • Author(s): A YOSHIDA, F SATO, F AKHTER, T HAQUE, T KATO, R TAKEDA, K HIGASHIYAMA, T FUJIO, H OHARA
  • Organizer: 4th International Congress on Neuropathic Pain
  • Place of Presentation: Metro Toronto Convention Centre, Toronto, Canada
• [Presentation] ラット島皮質から口腔顔面感覚が入力する三叉神経感覚核への直接投射 (2013)
  • Author(s): 佐藤文彦、加藤隆史、吉田篤
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポート高松(高松市)
• [Presentation] Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis and connections of the dorsal peduncular cortex with the insular cortex in rats (2013)
  • Author(s): Tahsinul Haque, Fatema Akhter, Fumihiko Sato, Takafumi Kato, Atsushi Yoshida
  • Organizer: 第7回 三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本歯科大学新潟生命歯学部・新潟大学駅南キャンパスときめいと、新潟市
• [Presentation] 三叉神経感覚核ならひに大脳皮質一次およひ二次体性感覚野から背側視床への投射の検討 (2013)
  • Author(s): 武田理恵子、大原春香、岡綾香、佐藤文彦、加藤隆史、山城隆、吉田篤
  • Organizer: 第7回 三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本歯科大学新潟生命歯学部・新潟大学駅南キャンパスときめいと、新潟市
• [Presentation] ラット島皮質から口腔顔面感覚が入力する三叉神経感覚核への直接投射 (2013)
  • Author(s): 佐藤文彦、加藤隆史、吉田篤
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポート高松（香川県高松市）
• [Presentation] Direct projections from the insular cortex to orofacial pain-related lower brainstem areas, especially to the trigeminal caudal subnucleus, in rats (2012)
  • Author(s): F SATO, F AKHTER, T HAQUE, T KATO, R TAKEDA, K HIGASHIYAMA, Y-BAE, A YOSHIDA
  • Organizer: Society of Neuroscience Annual Meeting
  • Place of Presentation: New Orleans, USA Society of Neuroscience Annual Meeting
• [Presentation] Projections to the trigeminal jaw-opening and jaw-closing premotoneurons in the nucleus of the solitary tract from the pharyngeal mucosa and the insular cortex in rats (2012)
  • Author(s): A OKA, R TAKEDA, F SATO, F AKHTER, TL HAQUE, T KATO, H OHARA, Y-C BAE, K TAKADA, A YOSHIDA
  • Organizer: The Ernest N. Morial Convention Center
  • Place of Presentation: New Orleans, USA Society of Neuroscience Annual Meeting
• [Presentation] Neuronal Mechanisms Controlling Jaw Movements. Nanosymposium on Motor Control of Orofacial Function (2012)
  • Author(s): A Yoshida, Y.-C. Bae
  • Organizer: Society of Neuroscience Annual Meeting
  • Place of Presentation: The Ernest N. Morial Convention Center. New Orleans, USA
• [Presentation] 大脳皮質一次および二次体性感覚野から三叉神経感覚核への投射の差異(シンポジウム) (2012)
  • Author(s): 吉田篤、加藤隆史、佐藤文彦、Tahsinul Haque
  • Organizer: 第54回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 奥羽大学ビッグアイ(郡山市)
• [Presentation] 大脳皮質一次および二次体性感覚野から三叉神経感覚核への投射の差異の解明 (2012)
  • Author(s): Tahsinul Haque、Fatema Akhter、佐藤文彦、加藤隆史、岡綾香、Barry J Sessle、吉田篤
  • Organizer: 第6回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本大学歯学部(東京)
• [Presentation] 孤束核における開口筋運動前ニューロンならびに閉口筋運動前ニューロンの存在およびその機能局在 (2012)
  • Author(s): 岡綾香、Fatema Akhter、Tahsinul Haque、佐藤文彦、加藤隆史、吉田篤
  • Organizer: 第6回三叉神経領域の感覚-運動統合機構研究会
  • Place of Presentation: 日本大学歯学部(東京)
• [Presentation] 大脳皮質から三叉神経感覚核・運動核への投射(シンポジウム) (2012)
  • Author(s): 吉田篤
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(甲府市)
• [Presentation] Neuronal Mechanisms Controlling Jaw Movements. Nanosymposium on Motor Control of Orofacial Function. (2012)
  • Author(s): A Yoshida, Y.-C. Bae
  • Organizer: Society of Neuroscience Annual Meeting
  • Place of Presentation: The Ernest N. Morial Convention Center. New Orleans, USA
• [Presentation] Projections to the trigeminal jaw-opening and jaw-closing premotoneurons in the nucleus of the solitary tract from the pharyngeal mucosa and the insular cortex in rats (2012)
  • Author(s): A Oka, R Takeda, F Sato, F Akhter, T Haque, T Kato, H Ohara, Y-C Bae, K Takada, A Yoshida
  • Organizer: Society of Neuroscience Annual Meeting
  • Place of Presentation: The Ernest N. Morial Convention Center. New Orleans, USA
• [Presentation] Direct projections from the insular cortex to orofacial pain-related lower brainstem areas, especially to the trigeminal caudal subnucleus, in rats. (2012)
  • Author(s): F Sato, F Akhter, T Haque, T Kato, R Takeda, K Higashiyama, Y-C Bae, A Yoshida
  • Organizer: Society of Neuroscience Annual Meeting
  • Place of Presentation: The Ernest N. Morial Convention Center. New Orleans, USA
• [Presentation] 大脳皮質から三叉神経感覚核・運動核への投射 (2012)
  • Author(s): 吉田篤
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学（甲府市）
• [Presentation] Differences in projections from the primary and secondary sonatosensory cortex to the trigeminal sensory nuclear complex in the rat
  • Author(s): T Haque, F Sato, A Oka, R Takeda, F Akhter, M. Higashiyama, T Kato, A Yoshida
  • Organizer: 日本神経科学会 Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
• [Presentation] Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats
  • Author(s): F Sato, T Hque, A Oka, K Higashiyama, K Yamada, F Akhter, H Ohara, T Fujio, M Yamamoto, K Uchino, T Kato, A Yoshida
  • Organizer: 日本神経科学会 Neuro2013
  • Place of Presentation: 国立京都国際会館、京都市
• [Presentation] 開口筋運動前ニューロンと閉口筋運動前ニューロンのラット孤束核内での機能局在
  • Author(s): 岡綾香、武田理恵子、大原春香、佐藤文彦、加藤隆史、山城隆、吉田篤
  • Organizer: 日本口腔科学会近畿地方部会
  • Place of Presentation: 大阪歯科大学創立100周年記念館、大阪市
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/admission/course/anat2.html
• [Remarks] 大阪大学大学院歯学研究科高次脳口腔機能学講座口腔解剖学第二教室HP
  • URL: http://www.dent.osaka-u.ac.jp/admission/course/anat2.html
• [Remarks]
  • URL: http://www.dent.osaka-u.ac.jp/admission/course/anat2.html