| Project/Area Number |
23592701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
YOSHIKO YUJI 広島大学, 医歯薬保健学研究院, 教授 (20263709)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Atsushi 藤田保健衛生大学, 医学部, 准教授 (90340265)
UCHIDA Soshi 産業医科大学, 医学部, 准教授 (60330990)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | FGF23 / 石灰化 / Phex / ASARM / 骨代謝 / KLotho / Klotho / ビタミンD / 骨細胞 |
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| Research Abstract |
We found that FG23, a phosphaturic factor, inhibits bone formation even though membrane Klotho (mKL), a coreceptor for FGF23 is not expressed in bone. It is known that mKL is cleaved and circulated as soluble KL (sKL). We confirmed that sKL supports the FGF23 effects on bone. Among FGF family members expressed in bone, FGF23, transcriptionally activated by 1,25(OH)2D3, stimulated transient activation of ERK1/2 only in mature steoblasts/osteocytes. This signaling downregulated Phex, with the resultant increase in the accumulation of ASARM peptide in bone. Administration of ASARM peptide decreased bone mineralization without affecting osteoblast proliferation and differentiation. These data describe a novel mechanism by which FGF23 regulates bone formation.
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