| Project/Area Number |
23592708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Tetsuya 九州歯科大学, 歯学科, 准教授 (70253458)
KATAOKA Shinnji 九州歯科大学, 歯学科, 助教 (80364149)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | iPS細胞 / 神経 / 神経ペプチド / 細胞分化 / 間葉系幹細胞 / 骨芽細胞 / 間葉系細胞 / ヘモキニン |
|---|
| Research Abstract |
To confirm the involvement of nerves for bone formation were examined for altered expression of the receptor of neuropeptides in the process to become osteoblasts from iPS cells. During three stage of cell differentiation; iPS, embryonic body, and osteoblast, the cells in iPS stage and early osteoblastic stage, the beta 2 adrenergic receptors and CGRP receptor were specifically expressed, and the NK-1 receptor is expressed specifically in the late differentiation of osteoblasts. These results suggest that neuropeptides affect the differentiation of osteoblast as the differentiation stage-dependent manner.
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