Mechanism and significance of Meckel's cartilage disappearance
Project/Area Number |
23592710
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
|
Research Institution | Meikai University |
Principal Investigator |
AMANO Osamu 明海大学, 歯学部, 教授 (60193025)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | メッケル軟骨 / 細胞死 / アポトーシス / オートファジー / 脂肪酸結合タンパク質 / 肝細胞増殖因子 / 軟骨吸収 / 器官培養 / マウス / 第1鰓弓 / 軟骨消失 / HGF |
Research Abstract |
During the development of mouse Meckel's cartilage, apoptosis was detected limitedly at 1) the mesenchymal condensation and 2) the perichondrium. No apoptotic cells were found in Meckel's chondrocytes; therefore, apoptosis does not participate in the degeneration of Meckel's cartilage. Because substantial proliferation and differentiation occur in the area of 1) and 2), apoptosis may play important roles in chondroblast differentiation for the development of Meckel's cartilage. Inhibition of apoptosis induced the dysplasia of Meckel's cartilage. In addition, immunolocalization of fatty acid-binding protein (FABP) in Meckel's and the growth plate cartilages, epidermal type FABP was exclusively expressed in the septoclast, a absorbing cells of uncalcified cartilage matrix.
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Report
(4 results)
Research Products
(37 results)
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[Book] 口腔科学2013
Author(s)
天野 修 他多数
Total Pages
1096
Publisher
朝倉書店
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