| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
During the development of mouse Meckel's cartilage, apoptosis was detected limitedly at 1) the mesenchymal condensation and 2) the perichondrium. No apoptotic cells were found in Meckel's chondrocytes; therefore, apoptosis does not participate in the degeneration of Meckel's cartilage. Because substantial proliferation and differentiation occur in the area of 1) and 2), apoptosis may play important roles in chondroblast differentiation for the development of Meckel's cartilage. Inhibition of apoptosis induced the dysplasia of Meckel's cartilage. In addition, immunolocalization of fatty acid-binding protein (FABP) in Meckel's and the growth plate cartilages, epidermal type FABP was exclusively expressed in the septoclast, a absorbing cells of uncalcified cartilage matrix.
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