| Project/Area Number |
23592711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
NONAKA Naoko 昭和大学, 歯学部, 准教授 (20307052)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394)
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
NAKAMACHI Tomoya 昭和大学, 遺伝子組み換え実験室, 助教 (30433840)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | PACAP / PACAPレセプター / 唾液腺 / 免疫組織学 / 発生学 / マウス / ドライマウス / 耳下腺 / 顎下腺 / 舌下腺 / 経鼻投与 / 免疫染色 |
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| Research Abstract |
We examined the ontogenic expression of PAC1R in mouse salivary glands. Salivary glands at 0, 3, 5, 7, 14 and 21 days postnatal male C57BL/6 mice were used for the immunohistochemical detection of PAC1R. In parotid gland, the acinus was not clearly formed and PAC1R was not detected until 14 days after birth. At 14 days, PAC1R was detected in the striated duct. In sublingual gland, acinus and duct were formed at 0 days after birth. PAC1R was constantly expressed in the striated duct from 0 day postnatal stage. In the case of submandibular gland, granular duct was not clearly identified and PAC1R was localized in striated first detected in striated duct until 21 days after birth. After 21 days, PAC1R was clearly detected at pillar cells in granular duct. Some of cells in the duct showed intense immunoreactions of PAC1R.
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