Localization and function of tight junction protein in gingival junctional epithelium.
| Project/Area Number |
23592713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Masataka 生理学研究所, 細胞器官研究系, 准教授 (10104275)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 付着上皮 / タイト結合 / 歯周組織 / 細胞接着 / DAT細胞 / 上皮性付着 / 細胞骨格 / フリーズフラクチャーレプリカ / 口腔上皮 |
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| Research Abstract |
The junctional epithelium (JE) is located between the cemento-enamel junction and the epithelium of which connects consecutively to the gingival oral epithelium, forming the dento-epithelial junction. JE cells have highly potential of cell adhesion, cell migration and cell division. In this study, to clarify the barrier function of the JE cell, especially the cells directly attached to the tooth (DAT cells), we examined the expression patterns of tight junction protein family, tight junction associate protein, by immuno-fluorescence microscopically and electron microscopically. In the JE cells, especially cytoplasm of the DAT cells, strongly positive reaction of Occludin, ZO-1 and Claudin-1, 4, 16 were observed. It is suggested that, JE may be comprised of two part, such as gingival connective tissue side JE cells, and so called DAT cells including apical portion of JE.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] The actin-specific reagent jasplakinolide induces apoptosis in primary rat parotid acinar cells2012
Author(s)
Matsuki-Fukushima, M., Hashimoto, S., Murakami, M., Ogata, Y., Fujita-Yoshigaki, J., Narita, T., Sugiya, H
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Journal Title
Arch Oral Biol
Volume: 57
Pages: 567-576
Related Report
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