| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Radiation-induced salivary gland hypofunction might be treated by regenerating blood vessels using cell transfer therapy. Then, we examined the availability of dental pulp cells (DPCs) which could be used as a cell source of endothelial cells. As a result, dental pulp cells contained cells retaining endothelial functions. Our results show that radiation-induced salivary hypofunction is partially reverted by transplantation of endothelial cell-induced DPCs. For these reasons, DPCs could be used as a cell source for the treatment of salivary gland hypofunction.
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