Elucidation of metabolites from periodontopathogenic bacteria on their biofilm formation and virulence.
| Project/Area Number |
23592721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
YOSHIDA Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Fuminobu 愛知学院大学, 歯学部, 教授 (50001962)
NAGANO Keiji 愛知学院大学, 歯学部, 講師 (60367620)
HASEGAWA Yoshiaki 朝日大学, 歯学部, 講師 (70460524)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 代謝産物 / 歯周病 / バイオフィルム / c-di-GMP / インドール / cyclic-di-GMP / 口腔細菌 |
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| Research Abstract |
Metabolites, including indole, have an effect on bacterial biofilm formation. In this study, study on tryptophanase producing indole was performed. Tryptophanase of Prevotella intermedia, which is one of periodontopathogenic bacteria, was purified and enzymatically characterized. In addition, capacity to produce indole and existence of the gene encoding tryptophanase were examined in 22 Prevetella species. Also, proteins to degrade and produce cyclic-di-nucleotides also investigated.
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Report
(4 results)
Research Products
(43 results)
