• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Promotion of bone formation using chondroitin sulfate E and application to bone regenerating biomaterials

Research Project

Project/Area Number 23592728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionTohoku University

Principal Investigator

MIYAZAKI Tatsuya  東北大学, 歯学研究科(研究院), 大学院非常勤講師 (90538638)

Co-Investigator(Kenkyū-buntansha) SUZUKI Osamu  東北大学, 大学院歯学研究科, 教授 (60374948)
Co-Investigator(Renkei-kenkyūsha) ANADA Takahisa  東北大学, 大学院歯学研究科, 准教授 (30398466)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsコンドロイチン硫酸 / インテグリン / オステオアクチビン / 破骨細胞 / 骨形成 / ヘパラン硫酸 / 骨代謝 / 骨芽細胞
Research Abstract

Chondroitin sulfate E enhances osteoblast differentiation and inhibits osteoclast differentiation. As a mechanism of action, it was demonstrated that CS-E bound to adhesion molecules such as both osteoactivin (OA) and its receptor, integrin. And also CS-E inhibited the osteoclast differentiation by blocking the interaction of OA to integrin and heparan sulfate. On the other hands, osteoblast produced biglycan core protein and E-unit of CS. The amount of these molecules transiently increased before osteoblast differentiation (mineralization). These results indicated that not only the exogenously-added CS-E but also endogenous CS contributed the differentiation of the cells. Based on the results in the present study, we will further investigate the potentiality of CS-E as an application to bone regenerating biomaterials.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2013 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes.2013

    • Author(s)
      Suzuki K, Anada T, Honda Y, Kishimoto KN, Miyatake N, Hosaka M, Imaizumi H, Itoi E, Suzuki O
    • Journal Title

      Key Eng Mater

      Volume: 529-530 Pages: 296-299

    • DOI

      10.4028/www.scientific.net/kem.529-530.296

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Synthetic octacalcium phosphate: A possible carrier for mesenchymal stem cells in bone regeneration.2013

    • Author(s)
      Suzuki O, Anada T
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: 2013 Pages: 397-400

    • DOI

      10.1109/embc.2013.6609520

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Proteome analysis of rat serum proteins adsorbed onto synthetic octacalcium phosphate crystals.2011

    • Author(s)
      Kaneko H, Kamiie J, Kawakami H, Anada T, Honda Y, Shiraishi N, Kamakura S, Terasaki T, Shimauchi H, Suzuki O
    • Journal Title

      Anal Biochem

      Volume: 418(2) Pages: 276-85

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 多硫酸化コンドロイチン硫酸の破骨細胞分化抑制作用におけるインテグリンの関与2013

    • Author(s)
      宮崎達也、宮内聡、穴田貴久、多和田明、鈴木治
    • Organizer
      第60回マトリックス研究会・第45回日本結合組織学会学術大会合同学術集会
    • Place of Presentation
      和歌山
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Biodegradable property of octacalcium phosphate-hyaluronic acid composites as bone substitute materials2013

    • Author(s)
      Suzuki K, Anada T, Miyazaki T, Miyatake N, Hosaka M, Imaizumi H, Itoi E, Suzuki O
    • Organizer
      The 23rd Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation Procedures
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 多硫酸化コンドロイチン硫酸の破骨細胞分化抑制作用におけるインテグリンの関与2013

    • Author(s)
      宮崎達也、宮内聡、穴田貴久、多和田明、鈴木治
    • Organizer
      第45回日本結合組織学会学術大会・第60回マトリックス研究会大会 合同学術大会
    • Place of Presentation
      和歌山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Biodegradable property of octacalcium phosphate-hyaluronic acid composites as bone substitute materials.2013

    • Author(s)
      K Suzuki, T Anada, T Miyazaki, N Miyatake, M Hosaka, H Imaizumi, E Itoi, O Suzuki
    • Organizer
      23th Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation Procedures
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨再生におけるリン酸オクタカルシウムと非晶質リン酸カルシウムの共存効果2013

    • Author(s)
      林 司史、穴田 貴久、髙橋 哲、鈴木 治
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of Basic-fibroblast Growth Factor on Osteogenic Differentiation of Rat2011

    • Author(s)
      Kawai T, Anada T, Masuda T, Honda Y, Sakai Y, Kato Y, Echigo S, Suzuki O.
    • Organizer
      24Th European Conference of European Society for Biomaterials
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.cfe.dent.tohoku.ac.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi