| Project/Area Number |
23592730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMURA Kensuke 新潟大学, 医歯学系, 教授 (90272822)
YAMADA Yoshiaki 新潟大学, その他, 理事 (80115089)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | QX-314 / TRPV1 / カプサイシン / 神経障害性疼痛 / 神経損傷 / C 線維 / 痛覚 / 麻酔 / 再生神経 |
|---|
| Research Abstract |
QX-314 with capsaicin has been reported to produce long-lasting block of acute pain. However, little is reported of their effectiveness on neuropathic pain (NP) after nerve injury which involves various biophysical and molecular changes in sensory neurons. In this study the effect of this combination was evaluated under NP and non-NP conditions after inferior alveolar nerve (IAN) transection.
The magnitude of QX-314 with capsaicin induced local anesthetic block varied under various conditions; however, no block was observed under NP conditions at 2 weeks after transection. Immunohistochemical study revealed that the number of regenerated neurons with transient receptor potential vanilloid 1 (TRPV1) expression gradually increased over time after transection. Unmyelinated neurons expressing TRPV1 regenerated slowly, especially in the presence of NP. In addition, TRPV1 expression shifted to myelinated fibers and this shift was more intense under NP than under non-NP conditions.
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