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The relationship between local anesthetic effect of QX-314 and TRPV1 expression following inferior alveolar nerve transection in rats

Research Project

Project/Area Number 23592730
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNiigata University

Principal Investigator

KITAGAWA Junichi  新潟大学, 医歯学系, 准教授 (50373006)

Co-Investigator(Kenkyū-buntansha) YAMAMURA Kensuke  新潟大学, 医歯学系, 教授 (90272822)
YAMADA Yoshiaki  新潟大学, その他, 理事 (80115089)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsQX-314 / TRPV1 / カプサイシン / 神経障害性疼痛 / 神経損傷 / C 線維 / 痛覚 / 麻酔 / 再生神経
Research Abstract

QX-314 with capsaicin has been reported to produce long-lasting block of acute pain. However, little is reported of their effectiveness on neuropathic pain (NP) after nerve injury which involves various biophysical and molecular changes in sensory neurons. In this study the effect of this combination was evaluated under NP and non-NP conditions after inferior alveolar nerve (IAN) transection.
The magnitude of QX-314 with capsaicin induced local anesthetic block varied under various conditions; however, no block was observed under NP conditions at 2 weeks after transection. Immunohistochemical study revealed that the number of regenerated neurons with transient receptor potential vanilloid 1 (TRPV1) expression gradually increased over time after transection. Unmyelinated neurons expressing TRPV1 regenerated slowly, especially in the presence of NP. In addition, TRPV1 expression shifted to myelinated fibers and this shift was more intense under NP than under non-NP conditions.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results) Presentation (12 results) (of which Invited: 5 results) Book (2 results)

  • [Journal Article] Involvement of astroglial glutamate-glutamine shuttle in modulation of the jaw-opening reflex following infraorbital nerve injury.2014

    • Author(s)
      Mostafeezur RM, Shinoda M, Unno S, Zakir HM, Takatsuji H, Takahashi K, Yamada Y, Yamamura K, Iwata K, Kitagawa J.
    • Journal Title

      Eur J Neurosci.

      Volume: inpress Issue: 12 Pages: 2050-2059

    • DOI

      10.1111/ejn.12562

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facilitation of the swallowing reflex with bilateral afferent input from the superior laryngeal nerve.2014

    • Author(s)
      Takahashi K, Shingai T, Saito I, Yamamura K, Yamada Y, Kitagawa J.
    • Journal Title

      Neurosci Lett.

      Volume: 562 Pages: 50-53

    • DOI

      10.1016/j.neulet.2014.01.017

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation.2013

    • Author(s)
      Takeda M, Takahashi M, Kitagawa J, Kanazawa T, Nasu M, Matsumoto S.
    • Journal Title

      Mol Pain.

      Volume: 9 Pages: 49-49

    • DOI

      10.1186/1744-8069-9-49

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] のどごしについての生理学的考察2013

    • Author(s)
      北川純一,高辻華子,高橋功次郎,真貝富夫
    • Journal Title

      日本味と匂学会誌

      Volume: 20 Pages: 143-149

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] のど越しの味と嚥下2013

    • Author(s)
      5.高辻華子,北川純一,真貝富夫
    • Journal Title

      JOHNS

      Volume: 29 Pages: 57-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] のどごしについての生理学的考察.2013

    • Author(s)
      北川純一,高辻華子,高橋功次郎,真貝富夫
    • Journal Title

      日本味と匂学会誌

      Volume: 20 Pages: 143-149

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] のど越しの味と嚥下.2013

    • Author(s)
      高辻華子,北川純一,真貝富夫
    • Journal Title

      JOHNS

      Volume: 29 Pages: 57-60

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cannabinoids facilitate the swallowing reflex elicited by the superior laryngeal nerve stimulation in rats.2012

    • Author(s)
      Mostafeezur RM, Zakir HM, Takatsuji H, Yamada Y, Yamamura K, Kitagawa J.
    • Journal Title

      PloS ONE

      Volume: 7(11) Issue: 11 Pages: e50703-e50703

    • DOI

      10.1371/journal.pone.0050703

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] e injury provides an essential delivery tool for neuropathic pain attenuation2012

    • Author(s)
      H.M. Zakir, R.M. Mostafeezur, A. Suzuki, S. Hitomi, T. Maeda, K. Seo, Y. Yamada, K. Yamamura, S. Lev, A.M. Binshtok, K. Iwata, J. Kitagawa
    • Journal Title

      PLoS One

      Volume: 7(9) Issue: 9 Pages: e44023-e44023

    • DOI

      10.1371/journal.pone.0044023

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of minocycline on the masticatory movements following the inferior alveolar nerve transection in freely moving rats.2012

    • Author(s)
      Mostafeezur RM, Zakir HM, Yamada Y, Yamamura K, Iwata K, Sessle BJ, Kitagawa J.
    • Journal Title

      Mol Pain

      Volume: 8 Pages: 27-27

    • DOI

      10.1186/1744-8069-8-27

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of the swallowing reflex by electrical stimulation of the posterior oropharyngeal region in awake humans2012

    • Author(s)
      Takatsuji H, Zakir HM, Mostafeezur RM, Saito I, Yamada Y, Yamamura K, Kitagawa J
    • Journal Title

      Dysphagia

      Volume: 27 Pages: 473-480

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the swallowing reflex by electrical stimulation of the posterior oropharyngeal region in awake humans.2012

    • Author(s)
      Takatsuji H, Zakir HM, Mostafeezur RM, Saito I, Yamada Y, Yamamura K, Kitagawa J.
    • Journal Title

      Dysphagia

      Volume: 27 Pages: 473-480

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of minocycline on the masticatory movements following the inferior alveolar nerve transection in freely moving rats.2012

    • Author(s)
      Mostafeezur RM, Zakir HM, Yamada Y, Yamamura K, Iwata K, Sessle BJ, Kitagawa J
    • Journal Title

      Mol Pain

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of the swallowing reflex by electrical stimulation of the posterior oropharyngeal region in awake humans.2012

    • Author(s)
      Takatsuji H, Zakir HM, Mostafeezur RM, Saito I, Yamada Y, Yamamura K, Kitagawa J
    • Journal Title

      Dysphagia

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Physiological and pharmacological actions involved in pharyngeal and laryngeal sensation.2014

    • Author(s)
      Kitagawa J.
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] のどごしについての生理学的考察.うま味研究会公開シンポジウム2013

    • Author(s)
      北川純一
    • Organizer
      うま味研究会公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Physiological and pharmacological actions involved in pharyngeal and laryngeal sensation2013

    • Author(s)
      Kitagawa J
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Facilitation of the swallowing reflex following administration of cannabinoids in rats.2013

    • Author(s)
      Takatsuji H, Kitagawa J, Yamada Y, Yamamura K.
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都江戸川区タワーホール船堀
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluation of the effect of QX-314 and TRPV1 expression following alveolar nerve injury2012

    • Author(s)
      Zakir HM, Kitagawa J, Yamada Y, Mostafeezur RM, Yamamura K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Upregulation of astroglia in the trigeminal motor nucleus involves in the modulation of the orofacial reflex after neruopathic pain2012

    • Author(s)
      Mostafeezur RM, Kitagawa J, Yamada Y, Zakir HM, Yamamura K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Facilitation of the swallowing reflex following administration of cannabinoids in rats2012

    • Author(s)
      Takatsuji H, Kitagawa J, Yamada Y, Yamamura K
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluating the effect of QX-314 and TRPV1 expression following inferior alveolar nerve transection in rats.2012

    • Author(s)
      Zakir HM, Kitagawa J, Yamada Y, Mostafeezur RM, Yamamura K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市、松本文化会館
    • Related Report
      2011 Research-status Report
  • [Presentation] Upregulation of astroglia in the trigeminal motor nucleus involves in the modulation of the orofacial reflex after neuropathic pain.2012

    • Author(s)
      4.Mostafeezur RM, Kitagawa J, Yamada Y, Zakir HM, Iwata K, Yamamura K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市、松本文化会館
    • Related Report
      2011 Research-status Report
  • [Presentation] カンナビノイドは嚥下反射を促進する2011

    • Author(s)
      北川純一, Mostafeezur RM, Zakir HM,山田好秋,山村健介
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-09-30
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] カンナビノイドは嚥下誘発を促進する2011

    • Author(s)
      北川純一, Hossain Md. Zakir, Rahman Md. Mostafeezur, 山田好秋, 山村健介
    • Organizer
      第53回歯科基礎医学会学術大会・総会(招待講演)
    • Place of Presentation
      岐阜市、長良川国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] のどごしについての生理学的考察

    • Author(s)
      北川純一
    • Organizer
      うま味研究会公開シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 口腔顔面痛の診断と治療ガイドブック2013

    • Author(s)
      北川純一
    • Total Pages
      229
    • Publisher
      医歯薬出版
    • Related Report
      2013 Final Research Report
  • [Book] 口腔顔面痛の診断と治療 ガイドブック2013

    • Author(s)
      北川純一 ほか (日本口腔顔面痛学会編)
    • Total Pages
      229
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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