| Project/Area Number |
23592733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
SOGAWA Chiharu 岡山大学, 医歯(薬)学総合研究科, 助教 (10253022)
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| Co-Investigator(Kenkyū-buntansha) |
KITAYAMA Shigeo 岡山大学, 大学院医歯薬学総合研究科, 教授 (80177873)
SOGAWA Norio 岡山大学, 大学院医歯薬学総合研究科, 准教 (30236153)
MORITA Katsuya 広島文化学園大学, 看護学部看護学科, 教授 (10116684)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経因性疼痛 / トランスポーター / モノアミン / 抗うつ薬 / GABA |
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| Research Abstract |
Neuropathic pain is defined with for a chronic or persistent pain to be generated by a pathophysiological alteration on the peripheral and/or central nervous system (CNS). Antidepressants are known as the inhibitors of monoamine neurotransmitter transporters (MATs) are therapeutically useful ligands for the treatment of neuropathic pain. However, they do not sometimes provide enough effects. We focused the change of MATs expression level in the CNS after the onset of the neuropathic pain. In this study, MATs mRNA level decreased in the brain stem after onset of the pain in limited neuropathic pain model. We suggested that the change of MAT expression in the CNS associated with therapeutic efficacy of antidepressants for the neuropathic pain.
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