Protein stabilization for TMEM16E
| Project/Area Number |
23592734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KEI Tobiume 広島大学, 医歯薬保健学研究院, 准教授 (40350037)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTA Kuniko 広島大学, 医歯薬保健学研究院, 助教 (40432679)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMATA Nobuyuki 広島大学, 医歯薬保健学研究院, 教授 (70242211)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | TMEM16E / GDD1 / LGMD2L / Anoctamin / TMEM16 / GDD / LGMD2 / 骨異形成 / 筋ジストロフィー / 顎骨幹骨異形成症 / 疾患責任遺伝子 / 優勢遺伝 / 劣性遺伝 / タンパク安定化 / tmem16 / anoctamin / lgmd2 / mmd3 / gdd |
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| Research Abstract |
We identified TMEM16E has a constitutive susceptibility to proteasome-dependent degradation, which was compromized by PI3K inhibitors or addition of a chemical chaperon in vitro.Since TMEM16E gains protein stability in skeltal muscle tissue,our results suggested tissue-specific environments (e.g., energy metabolism and molecular chaperon) may support stabilization of TMEM16E.
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Report
(4 results)
Research Products
(19 results)
