Characterization of LPS-induced hyper OPN osteoblasts
| Project/Area Number |
23592739
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
BANDOW Kenjiro 鹿児島大学, 医歯(薬)学総合研究科, 助教 (50347093)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUGUCHI Tetsuya 鹿児島大学, 医歯学総合研究科, 教授 (10303629)
OHNISHI Tomokazu 鹿児島大学, 医歯学総合研究科, 准教授 (30244247)
KUSUYAMA Joji 鹿児島大学, 医歯学総合研究科, 助教 (70596105)
KAKIMOTO Kyoko 鹿児島大学, 医歯学総合研究科, 助教 (40274849)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | OPN / osteoblast / LPS / Lmw-ptp / FAK / elaidic acid / 高 OPN 骨芽細胞 / メカニカルストレス / 骨芽細胞 / 破骨細胞 / ケモカイン / パルミチン酸 |
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| Research Abstract |
LPS-induced hyper OPN osteoblasts have an ability of osteoblastic differentiation and respond to mechanical stress less than low OPN cells. Lmw-ptp is up-regulated in hyper OPN osteoblast and decreases phosphorylation of FAK induced by mechanical stress. Though, it is unclear how OPN interacts with Lmw-ptp and FAK. Hyper OPN osteoblasts may be an intriguing target to develop therapeutic drugs against inflammatory bone diseases.
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Report
(4 results)
Research Products
(18 results)
