| Project/Area Number |
23592740
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
OHNISHI Tomokazu 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (30244247)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUGUCHI Tetsuya 鹿児島大学, 医歯学総合研究科, 教授 (10303629)
KAKIMOTO Kyoko 鹿児島大学, 医歯学総合研究科, 助教 (40274849)
BANDOW Kenjiro 鹿児島大学, 医歯学総合研究科, 助教 (50347093)
KUSUYAMA Joji 鹿児島大学, 医歯学総合研究科, 助教 (70596105)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | JNK / DUSP / T細胞 / 肥満 / NPY / コレシストキニン / ヘルパーT細胞 / DUSP16 / MKP-M / T 細胞 / サイトカイン / 視床下部 |
|---|
| Research Abstract |
We previously prepared MKP-M CS mice, which specifically express dominant negative DUSP16 in T cells. These mice had abnormality in helper T cell functions. We observed that MKP-M CS mice increased in food intake to obtain high body mass. Therefore, we analyzed expressions of various neuropeptides in their hypothalamus. We found that MKP-M CS mice decreased a reduction of expression of NPY, which stimulates feeding, during food feeding. Next, we detected expression of cholecystokinin (CCK), which is a satiety signal peptide, in small intestine. We found that T cell specific DUSP16 dominant negative decreased CCK expression in intestine of MKP-M CS mice during feeding. In summary, MKP-M mice increased inhibition CCK expression in small intestine and reduction of NPY in hypothalamus to increase in body mass and food intake during feeding.
|
