Identification of novel signaling molecules controling immune surveillance
| Project/Area Number |
23592741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONISHI Tomokazu 鹿児島大学, 医歯学総合研究科, 准教授 (30244247)
BANDOW Kenjiro 鹿児島大学, 医歯学総合研究科, 助教 (50347093)
KUSUYAMA Joji 鹿児島大学, 医歯学総合研究科, 助教 (70596105)
KAKIMOTO Kyoko 鹿児島大学, 医歯学総合研究科, 助教 (40274849)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シグナル伝達 / メカニカルストレス / T細胞 / 細胞分化 / Th1/Th2 / 骨芽細胞 / ケモカイン / サイトカイン / 免疫応答 / 細胞内シグナル伝達 / LPS / TLR / 紫外線 / マクロファージ / ＴＬＲシグナル伝達 / フォスファターゼ / インターフェロン / キナーゼ / ヒストンアセチル化 / ヘルパーＴ細胞 / JNK |
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| Research Abstract |
The good control of immune surveillance is socially significant as it is essential for the prevention of severe diseases. However, the molecular mechanisms of immune surveillance have not been well defined. Recently, the relationship between exercise and immunity has attracted a lot of attention. Here, we have shown that DUSP16, a JNK-specific MAP kinase phosphatase, is functionally important to deviate Th1/Th2 balance toward Th2. Our research results have also revealed that Cot/Tpl2, an upstream kinase of the MAP kinase cascade, functionally decreases IL-12 p40 mRNA. Thus, these two molecules are considered as key controlling molecules of immune surveillance. We have furthermore shown that the ultrasound, one of the mechanical stresses, can be anti-inflammatory by inhibiting TLR signals.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.2014
Author(s)
Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.
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Journal Title
PLoS ONE
Volume: 9
Issue: 2
Pages: e89615-e89615
DOI
Related Report
Peer Reviewed
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