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Identification of novel signaling molecules controling immune surveillance

Research Project

Project/Area Number 23592741
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionKagoshima University

Principal Investigator

MATSUGUCHI TETSUYA  鹿児島大学, 医歯(薬)学総合研究科, 教授 (10303629)

Co-Investigator(Kenkyū-buntansha) ONISHI Tomokazu  鹿児島大学, 医歯学総合研究科, 准教授 (30244247)
BANDOW Kenjiro  鹿児島大学, 医歯学総合研究科, 助教 (50347093)
KUSUYAMA Joji  鹿児島大学, 医歯学総合研究科, 助教 (70596105)
KAKIMOTO Kyoko  鹿児島大学, 医歯学総合研究科, 助教 (40274849)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシグナル伝達 / メカニカルストレス / T細胞 / 細胞分化 / Th1/Th2 / 骨芽細胞 / ケモカイン / サイトカイン / 免疫応答 / 細胞内シグナル伝達 / LPS / TLR / 紫外線 / マクロファージ / TLRシグナル伝達 / フォスファターゼ / インターフェロン / キナーゼ / ヒストンアセチル化 / ヘルパーT細胞 / JNK
Research Abstract

The good control of immune surveillance is socially significant as it is essential for the prevention of severe diseases. However, the molecular mechanisms of immune surveillance have not been well defined. Recently, the relationship between exercise and immunity has attracted a lot of attention. Here, we have shown that DUSP16, a JNK-specific MAP kinase phosphatase, is functionally important to deviate Th1/Th2 balance toward Th2. Our research results have also revealed that Cot/Tpl2, an upstream kinase of the MAP kinase cascade, functionally decreases IL-12 p40 mRNA. Thus, these two molecules are considered as key controlling molecules of immune surveillance. We have furthermore shown that the ultrasound, one of the mechanical stresses, can be anti-inflammatory by inhibiting TLR signals.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (23 results) Book (3 results)

  • [Journal Article] Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation2014

    • Author(s)
      Nakao J, Fujii Y, Kusuyama J, Bandow K, Kakimoto K, Ohnishi T, Matsuguchi T
    • Journal Title

      Bone

      Volume: 58 Pages: 17-25

    • DOI

      10.1016/j.bone.2013.09.018

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-Time Treatment by Low-Dose N-Acetyl-L-Cysteine Enllanoes Proinflammatory Cytokine Expressions in LPS-Stimulated Maerophages2014

    • Author(s)
      Ohnishi T, Bandow K, Kakimoto K, Kusuyama J, Matsuguchi T
    • Journal Title

      PLos One

      Volume: 9 Issue: 2 Pages: 10330-44

    • DOI

      10.1371/journal.pone.0087229

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tp12-MEK-ERK Signaling Pathway2014

    • Author(s)
      Kusuyama J, Bandow K, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T
    • Journal Title

      the Journal of Biological Chemistry

      Volume: 289 Issue: 15 Pages: 10330-10344

    • DOI

      10.1074/jbc.m113.546382

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.2014

    • Author(s)
      Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 2 Pages: e89615-e89615

    • DOI

      10.1371/journal.pone.0089615

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats2013

    • Author(s)
      Matsui I
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 304 Issue: 6 Pages: 751-60

    • DOI

      10.1152/ajprenal.00329.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 最新の骨粗鬆症学 ー骨粗鬆症の最新知見―: 骨芽細胞の分化調節機構2013

    • Author(s)
      松口 徹也
    • Journal Title

      日本臨床

      Volume: 71 Pages: 43-47

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 最新の骨粗鬆症学 ー骨粗鬆症の最新知見―: 骨芽細胞の分化調節機構2013

    • Author(s)
      松口徹也
    • Journal Title

      日本臨床

      Volume: 71 Suppl 2 Pages: 43-47

    • Related Report
      2012 Research-status Report
  • [Journal Article] Mast Cells as Critical Effectors of Host Immune Defense against Gram-negative Bacteria2012

    • Author(s)
      Matsuguchi T
    • Journal Title

      Curr Med Chem

      Volume: 19(10) Pages: 1432-1442

    • Related Report
      2013 Final Research Report
  • [Journal Article] LPS-induced chemokine expression in both MyD88-dependent and independent manners is regulated by Co/Tpl2-ERK axis in macrophages2012

    • Author(s)
      Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T.
    • Journal Title

      FEBS Letters

      Volume: 585 Issue: 10 Pages: 1540-6

    • DOI

      10.1016/j.febslet.2012.04.018

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mast Cells as Critical Effectors of Host Immune Defense against Gram-negative Bacteria.2012

    • Author(s)
      Matsuguchi T
    • Journal Title

      Curr Med Chem

      Volume: 19 Pages: 1432-1442

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation2011

    • Author(s)
      Musikacharoen T, Bandow K, Kakimoto K, Kusuyama J, Onishi T, Yoshikai Y, Matsuguchi T
    • Journal Title

      J Biol Chem

      Volume: 286(28) Issue: 28 Pages: 24896-905

    • DOI

      10.1074/jbc.m111.245019

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨芽細胞のLIPUS応答性はオステオポンチン発現によって減弱する2014

    • Author(s)
      楠山譲二、坂東健二郎、社本光央、柿元協子、大西智和、松口徹也
    • Organizer
      第17回超音波骨折治療研究会
    • Place of Presentation
      兵庫
    • Year and Date
      2014-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨芽細胞のLIPUS応答性はオステオポンチン発現によって減弱する2014

    • Author(s)
      楠山譲二、坂東健二郎、社本光央、柿元協子、大西智和、松口徹也
    • Organizer
      第17回超音波骨折治療研究会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨芽細胞分化に対する遊離脂肪酸の影響2013

    • Author(s)
      坂東健二郎、楠山譲二、久留光博、柿元協子、大西智和、松口徹也
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 自然免疫に重要なMyd88とIL-1βは機械的刺激による骨芽細胞のケモカインの発現誘導に関与する2013

    • Author(s)
      前田綾、坂東健二郎、宮脇正一、松口徹也
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Year and Date
      2013-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] MAPキナーゼフォスファターゼ(DUSP)mRNAの不安定性による細胞ストレス反応の制御機構2013

    • Author(s)
      松口徹也、楠山譲二、坂東健二郎、柿元協子、大西智和
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] CXCL3は脂肪分化を正に制御する2013

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] PS-induced IL-12 p40 mRNA is regulated by MCPIP-1 ribonuclease expression through Cot/Tpl2-MEK-ERK axis in macrophages2013

    • Author(s)
      柿元協子、坂東健二郎、楠山譲二、久留光博、大西智和、松口徹也
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] CXCL3は脂肪分化を正に制御する2013

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第18回アディポサイエンスシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2013-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス頭蓋冠由来骨芽細胞の分化と解糖系の関係2013

    • Author(s)
      大西智和、坂東健二郎、柿元協子、松口徹也
    • Organizer
      2nd Joint meeting of the international bone and mineral society and the Japanese society for bone and mineral research
    • Place of Presentation
      神戸
    • Year and Date
      2013-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-intensity pulsed ultrasound (LIPUS) suppresses adipogenesis and promotes osteogenesis of mesenchymal stem cells through ROCK-Cot/Tpl2-MEK-ERK signaling pathway2013

    • Author(s)
      Kusuyama J, Bandow K, Kakimoto K, Ohnishi T, Matsuguchi T
    • Organizer
      Toronto University Research Day
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2013-02-12
    • Related Report
      2013 Final Research Report
  • [Presentation] MAPキナーゼフォスファターゼ(DUSP)mRNAの不安定性による細胞ストレス反応の制御機構2013

    • Author(s)
      松口徹也、楠山譲二、坂東健二郎、柿元協子、大西智和
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] CXCL3は脂肪分化を正に制御する2013

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      アディポサイエンスシンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] LPS-induced IL-12 p40 mRNA is regulated by MCPIP-1 ribonuclease expression through Cot/Tpl2-MEK-ERK axis in macrophages、2013

    • Author(s)
      柿元協子、坂東健二郎、楠山譲二、久留光博、大西智和、松口徹也
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自然免疫に重要なMyd88 とIL-1βは機械的刺激による骨芽細胞のケモカインの発現誘導に関与する2013

    • Author(s)
      前田綾、坂東健二郎、宮脇正一、松口徹也
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] LIPUS(低出力超音波)刺激による間葉系幹細胞の分化方向調節機構2012

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] N-アセチルシステインによる活性化マクロファージにおける炎症性サイトカインの発現上昇2012

    • Author(s)
      大西智和、坂東健二郎、柿元協子、楠山譲二、松口徹也
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 間葉系幹細胞の骨/脂肪分化によるケモカインの発現パターン2012

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] マクロファージにおけるLPSによるCot/Tpl2-ERK経路を介したケモカインの誘導2012

    • Author(s)
      坂東健二郎,楠山譲二,柿元協子,大西智和,松口徹也
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2013 Final Research Report
  • [Presentation] Low-Intensity Pulsed Ultra Sound(LIPUS)が炎症性遺伝子発現に及ぼす影響2012

    • Author(s)
      松口徹也,楠山譲二,坂東健二郎,柿元協子,大西智和
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] マクロファージにおけるLPS によるCot/Tpl2-ERK 経路を介したケモカインの誘導2012

    • Author(s)
      坂東健二郎, 楠山譲二, 柿元協子, 大西智和, 松口徹也
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島
    • Related Report
      2012 Research-status Report
  • [Presentation] 間葉系幹細胞の骨/脂肪分化によるケモカインの発現パターン2012

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] LIPUS(低出力超音波)刺激による間葉系幹細胞の分化方向調節機構2012

    • Author(s)
      楠山譲二、坂東健二郎、柿元協子、大西智和、松口徹也
    • Organizer
      第11回日本超音波治療研究会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Research-status Report
  • [Presentation] JNK特異的フォスファターゼDUSP16のヘルパーT細胞分化における機能的役割2011

    • Author(s)
      松口徹也、坂東健二郎、楠山譲二、柿元協子、大西智和
    • Organizer
      歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Book] アンチエイジングシリーズ3骨研究最前線代謝・疾病のメカニズムから再生医療・創薬・リハビリ機器・機能性食品開発まで:骨免疫と臨床応用の可能性2013

    • Author(s)
      松口徹也
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Final Research Report
  • [Book] アンチエイジングシリーズ3 骨研究最前線 代謝・疾病のメカニズムから再生医療・創薬・リハビリ機器・機能性食品開発まで:骨免疫と臨床応用の可能性2013

    • Author(s)
      松口 徹也
    • Total Pages
      9
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Book] Roles of Kinases in Osteoblast Function, Advances in Protein Kinases, Gabriela Da Silva Xavier (Ed.)2012

    • Author(s)
      Matsuguchi T
    • Publisher
      InTech
    • Related Report
      2013 Final Research Report 2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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