Cell differentiation from basal cell to taste bud: Conditional recombination approach
| Project/Area Number |
23592742
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
MIURA Hirohito 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (80353936)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARADA Shuitsu 鹿児島大学, 医歯学総合研究科, 教授 (60128452)
NAKAYAMA Ayumi 鹿児島大学, 医歯学総合研究科, 助教 (10398290)
OOKI Makoto 鹿児島大学, 医歯学総合研究科, 助教 (60596104)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 味覚 / 細胞分化 / 味蕾 / 国際情報交換 |
|---|
| Research Abstract |
Taste buds, the peripheral sensory organ for gustation, are comprised of 30-100 elongate cells and a small number of ovoid cells situated in the basal region. The basal cells in taste buds selectively express Shh, an evolutionally conserved signaling molecule. In this study, the Shh-expressing basal cells were genetically labeled with the expression of LacZ or EGFP marker protein by inducible gene recombination. Analysis of marker expression revealed (1) Shh-expressing cells are postmitotic, (2) Shh-expressing basal cells give rise to all three functional cell types in taste buds, type I (glia-like), type II (sweet, umami and bitter sensing ) and type III (sour sensing) cells.
|
Report
(4 results)
Research Products
(25 results)
