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Regulation of inflammation and innate immunity by TLR agonists

Research Project

Project/Area Number 23592747
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

SUZUKI Keiko  昭和大学, 歯学部, 講師 (50119187)

Co-Investigator(Kenkyū-buntansha) YAMADA Shoji  昭和大学, 歯学部, 名誉教授 (00111617)
Co-Investigator(Renkei-kenkyūsha) ISHII Masaru  大阪大学, 大学院医学系研究科・医学部, 教授 (10324758)
TANIMURA Akihiko  北海道医療大学, 歯学部, 教授 (70217149)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炎症性骨破壊 / Toll-like receptor / in vivo imaging / 自然免疫 / 骨代謝治療薬 / 炎症 / 免疫 / 歯周病 / グラム陽性菌 / 骨代謝 / イメージング / 骨吸収治療薬
Research Abstract

Bacteria are a common cause of periodontitis, in which accelerated alveolar bone resorption may ultimately lead to tooth loss. It is well established that bacteria interact with host cells through components of their cell wall by binding to corresponding Toll-like receptors (TLRs). Among these, LPS, a ligand for TLR4, is the most clearly defined molecule as a potent inducer of osteoclastogenesis and bone resorption. On the other hand, the fact that TLR2, in addition to TLR4, was prominently expressed in both precursors and differentiated osteoclasts, raised the possibility that TLR2 is involved in periodontitis-associated osteolysis. In the present study, we studied whether Pam3CSK4, a ligand for TLR2, caused bone resorption in vivo. The results showed that Pam3CSK4 caused even severer alveolar bone resorption as compared to LPS, indicating that transition time from inflammation to innate immunity was prolonged in Pam3CSK4-induced osteolysis compared to that of LPS.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(21 results)

All 2018 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner2018

    • Author(s)
      Tkeuchi A, Okubo K
    • Journal Title

      PLOS ONE

      Volume: 8 Pages: 0173147-0173147

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Delphinidin, One of the Major Anthocyanidins2014

    • Author(s)
      Moriwaki S, Suzuki K, Muramatsu M, Nomura A, Inoue F, Into T, Yoshiko Y, Niida S
    • Journal Title

      PLOS ONE

      Volume: (PLOS ONE)

    • DOI
      10.1371/journal.pone.0097177
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fructooligosaccharide Consumption Improves the Decreased Cortical Bone Following Gastrectomy in Rats2013

    • Author(s)
      Sakai N, Morohashi T, Yamada S
    • Journal Title

      Dent Med Res

      Volume: 33(in press)

    • NAID
      10031166800
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pam3CSK4, a TLR2 Agonist, Induces Osteoclastogenesis in RAW 264.7 Cells2012

    • Author(s)
      Yano A, Suzuki K, Yamamoto M, Yamada S
    • Journal Title

      Dent Med Res

      Volume: 32 Pages: 181-188

    • NAID
      10031141316
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tea polyphenols inhibit rat osteoclast formation and differentiation2012

    • Author(s)
      Oka Y, Iwai S, Amano H, Irie Y, Yatomi K, Ryu K, Yamada S, Inagaki K, Oguchi K
    • Journal Title

      J Pharmacol Sci

      Volume: 118 Pages: 55-64

    • NAID
      10030454159
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pam3CSK4, a TLR2 Agonist, Induces Osteoclastogenesis in RAW 264.7 Cells.2012

    • Author(s)
      Akiko Yano, Keiko Suzuki, Matsuo Yamamoto and Shoji Yamada
    • Journal Title

      Dental Medicine Research

      Volume: 32 Pages: 181-188

    • NAID
      10031141316
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pam3CSK4, a TLR2 agonist, induces osteoclastogenesis RANK/RANKL-independently in RAW 264.7 cells2012

    • Author(s)
      Akiko Yano, Keiko Suzuki, Matsuo Yamamoto and Shoji Yamada
    • Journal Title

      Dent Med Res

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of mechanical stimulation on the expression of Na+/Ca2+ exchanger mRNA and orientation of F-actin filaments in cultured osteoblastic cells2011

    • Author(s)
      Sakai N, Suzuki K, Morohashi T, Yamada S
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 117-123

    • NAID
      10027973016
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新規ビスホスホネート[4-(methylthio) phenylthio] methanebisphosphonateのanabolicな作用2011

    • Author(s)
      鳴沢佑香,千葉美麗,鈴木恵子,村上忍,竹山禎章,山田庄司,五十嵐薫,篠田壽
    • Journal Title

      Clinical Calcium

      Volume: 21 Pages: 756-757

    • Related Report
      2013 Final Research Report
  • [Presentation] 新規ビスホスホネートが卵巣摘出ラットの骨形成に及ぼす作用2014

    • Author(s)
      滝澤愛子、千葉美麗、太田岳、安田真弓、鈴木恵子、篠田壽、五十嵐薫
    • Organizer
      第73回日本矯正歯科学会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規ビスホスホネートMPMBPが骨粗鬆症モデルラットの骨形成に及ぼす影響2014

    • Author(s)
      滝澤愛子、千葉美麗、太田岳、安田真弓、鈴木恵子、篠田壽、五十嵐薫
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs calvarial and alveolar bone in vivo2013

    • Author(s)
      Suzuki K, Arimoto T, Morohashi T, Sakai N, Karakawa A, Shinoda H, Yamada S
    • Organizer
      15^<th> International Congress of Immunology
    • Place of Presentation
      Milan
    • Related Report
      2013 Final Research Report
  • [Presentation] 炎症性骨破壊におけるToll-like receptorの役割2013

    • Author(s)
      鈴木恵子
    • Organizer
      薬力学研究会受賞講演
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs calvarial and alveolar bone in vivo2013

    • Author(s)
      Keiko Suzuki, Takafumi Arimoto, Tomio Morohashi, Nobuhiro Sakai, Akiko Karakawa, Hisashi Shinoda and Shoji Yamada
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2012 Research-status Report
  • [Presentation] 植物アントシアニジンの骨破壊抑制効果2012

    • Author(s)
      森脇佐和子,鈴木恵子,井上文秀,村松昌,野村篤志,新飯田俊平
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces in vitro osteoclastogenesis RANKL-independently and resorbs alveolar bone in rats2011

    • Author(s)
      Yano A, Suzuki K, Morohashi T, Arimoto T, Karakawa A, Igarashi T, Shinoda H, Yamamoto M, Yamada S
    • Organizer
      ASBMR 2011 Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2アゴニストであるPam3CSK4による破骨細胞形成とラット上顎口蓋骨骨吸収作用について2011

    • Author(s)
      矢野亜希子,鈴木恵子,諸橋富夫,有本隆文,唐川亜希子,五十嵐武,山本松男,山田庄司
    • Organizer
      第31回昭和歯学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2アゴニストであるPam3CSK4による破骨細胞形成とラット上顎口蓋骨骨吸収作用について2011

    • Author(s)
      矢野亜希子,鈴木恵子,諸橋富夫,唐川亜希子,山本松男,山田庄司
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2アゴニストであるPam3CSK4による破骨細胞形成とマウス頭蓋骨骨吸収作用について2011

    • Author(s)
      矢野亜希子,鈴木恵子,山本松男,山田庄司
    • Organizer
      第54回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Pam3CSK4, a TLR2 agonist, induces osteoclastogenesis and alveolar bone resorption in rats2011

    • Author(s)
      Akiko Yano, Keiko Suzuki, Matsuo Yamamoto and Shoji Yamada
    • Organizer
      ASBMR 2011 Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] 炎症性骨破壊におけるToll-like receptorの役割

    • Author(s)
      鈴木恵子
    • Organizer
      薬力学研究会講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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