| Project/Area Number |
23592750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
INOUE Tomio 昭和大学, 歯学部, 教授 (70184760)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Shiro 昭和大学, 歯学部口腔生理学教室, 助教 (60384187)
NAKAYAMA Kiyomi 昭和大学, 歯学部口腔生理学教室, 助教 (00433798)
MOCHIZUKI Ayako 昭和大学, 歯学部口腔生理学教室, 助教 (10453648)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 口腔生理学 / 咀嚼 / 脳幹スライス標本 / 三叉神経運動ニューロン / 樹状突起 / ケージドグルタミン酸 / カルシウムチャネル / カルシウムイオン動態 / 二光子励起顕微鏡 / 情報処理 / 運動ニューロン / カルシウムイオン / 三叉神経 / ２光子励起顕微鏡 |
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| Research Abstract |
The dendrites of neurons have long been considered as electrically passive structures that merely transmit synaptic potentials to the soma. However, the recent studies have shown that the dendrites of some neurons are not only passive but also contain voltage-sensitive conductances that cause an excitation and affect synaptic integration. In this study, we used the two-photon calcium imaging techniques to explore the active dendritic properties in response to the action potentials (APs) in soma of trigeminal motoneurons. We found that the dendrites of trigeminal motoneurons have active properties that could serve as the amplification and modification of synaptic inputs and the regulation of dendritic excitability contribute to the prevention of irregular excitability of trigeminal motoneurons in pathological conditions such as bruxism.
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