| Project/Area Number |
23592751
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Maki 東京歯科大学, 歯学部, 客員講師 (90582346)
SATO Masaki 東京歯科大学, 生理学講座, 助手 (80598855)
SOBHAN Ubaidus 東京歯科大学, 生理学講座, 非常勤講師 (90598856)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 歯学 / シグナル伝達 / 神経科学 / 象牙芽細胞 / 細胞間コミュニケーション / 神経伝達 / 痛覚 / 歯内療法学 / TRPチャネル群 / 感覚受容 / 歯痛 |
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| Research Abstract |
Mechanical-, thermal-, and chemical-stimuli to the surface of exposed dentin induce dentinal pain. However, mechanisms understanding dentinal pain remain to be clarified. We examined intercellular communication between odontoblasts and trigeminal ganglion (TG) neurons during direct mechanical stimulation of odontoblasts. The results showed that ATP released from mechanically stimulated odontoblasts via pannexin-1 in response to activation of mechano-sensitive transient receptor potential channels acts as neurotransmitter, to transduce a sensory signal to TG neurons by activation of ATP receptors. We suggest that odontoblasts are sensory receptor cells to drive sensory transduction sequence for dentinal pain.
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