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A novel visualization approach on a 64-row multidetector CT perfusion in the early detection of subclinical cervical lymph node metastases

Research Project

Project/Area Number 23592759
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

HAYASHI Takafumi  新潟大学, 医歯学系, 教授 (80198845)

Co-Investigator(Kenkyū-buntansha) 斎藤 美紀子  新潟大学, 医歯学系, 助教 (90401760)
Co-Investigator(Renkei-kenkyūsha) SAKU Takashi  新潟大学, 医歯学系, 教授 (40145264)
Research Collaborator SHIMIZU Satoshi  ザイオソフト株式会社, マーケティング部, 部長
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsCT perfusion / 口腔癌 / 頸部リンパ節転移 / 灌流速度 / 造影CT / ダイナミックCT / 画像診断 / CT潅流画像
Research Abstract

We estimated the clinical utility of the CT perfusion in the early detection of subclinical lymph node metastases in six patients with oral cancer. CT perfusion examination was performed using a 64-row multidetector CT scanner and the perfusion parameters (single compartment kinetic model: SC Flow, deconvolution method: BF, BV and MTT) were calculated with dedicated software (ziostation2). Clinically negative eight lymph nodes with a minimal diameter of 10 mm or less were enrolled in this study and seven of them were proved to be metastatic by histopathological examination. Among with the above-mentioned parameters, SC flow value of three metastatic nodes showed a 50 % decrease compared to that of the benign contralateral lymph nodes in the same neck level. We deemed that this "hypoperfusion" phenomenon might be one of the novel diagnostic criteria in the small metastatic lymph nodes without known evidence of metastases on the CT perfusion study.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(18 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Detection of subsequent cervical lymph node metastasis in a patient with gingival carcinoma using computed tomography perfusion with a single-compartment kinetic model2014

    • Author(s)
      Hayashi T, Tanaka R, Yamazaki M, Cheng J, Oda Y, Hayashi H, Takeishi E, Honma K, Nishiyama H
    • Journal Title

      Oral Radio

      Volume: 30(2) Pages: 186-191

    • DOI

      10.1007/s11282-013-0153-1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 口腔癌頸部リンパ節転移診断におけるCT perfusionの応用2013

    • Author(s)
      林孝文,新垣元基,曽我麻里恵,池真樹子,新國農,小山純市,田中礼,勝良剛詞,西山秀昌
    • Organizer
      第113回新潟臨床放射線学会
    • Place of Presentation
      新潟市(新潟大学医学部)
    • Year and Date
      2013-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌頸部リンパ節転移診断におけるCT灌流画像の応用―deconvolution法とsingle compartment法との比較―2013

    • Author(s)
      林孝文,新垣元基,曽我麻里恵,池真樹子,新國農,小山純市,田中礼,勝良剛詞,西山秀昌
    • Organizer
      PO法人日本歯放射線学会第18回臨床画像大会および教育研修会
    • Place of Presentation
      東京(東京歯科大学水道橋校舎)
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical significance of CT perfusion in assessing the subsequent lymph node metastases in patients with oral cancer2013

    • Author(s)
      Hayashi T, Ike M, Nikkuni Y, Koyama J, Tanaka R, Katsura K, Nishiyama H
    • Organizer
      The 19th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Bergen, Norway (Grieghallen)
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 頸部リンパ節転移診断へのCT perfusionの応用2013

    • Author(s)
      林孝文,新國農,小林正治,児玉泰光,勝良剛詞
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2013 Final Research Report
  • [Presentation] 頸部リンパ節転移診断へのCT perfusionの応用2013

    • Author(s)
      林 孝文 ,新國 農 ,小林正治 ,児玉泰光 ,勝良剛詞
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔癌頸部リンパ節転移診断における CT灌流画像の応用―deconvolution 法と single compartment 法との比較―2013

    • Author(s)
      林 孝文,新垣元基,曽我麻里恵,池真樹子,新國 農,小山純市,田中 礼,勝良剛詞,西山秀昌
    • Organizer
      NPO法人日本歯放射線学会第18回臨床画像大会および教育研修会
    • Place of Presentation
      東京(東京歯科大学水道橋校舎)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical significance of CT perfusion in assessing the subsequent lymph node metastases in patients with oral cancer2013

    • Author(s)
      Takafumi HAYASHI, Makiko IKE, Yutaka NIKKUNI, Jun-ichi KOYAMA, Ray TANAKA, Kouji KATSURA, Hideyoshi NISHIYAMA
    • Organizer
      19th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Bergen, Norway
    • Related Report
      2012 Research-status Report
  • [Presentation] 潜在的頸部リンパ節転移へのCT perfusionの応用2012

    • Author(s)
      林孝文,池真樹子,新国農,斎藤美紀子,小山純市,田中礼,勝良剛詞,西山秀昌
    • Organizer
      第53回日本歯科放射線学会学術大会
    • Place of Presentation
      盛岡市(岩手県民情報交流センター)
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] CT perfusionとUS elastographyにより後発頸部リンパ節転移を評価した舌癌の1例2012

    • Author(s)
      林孝文
    • Organizer
      第31回日本画像医学会
    • Place of Presentation
      東京(東京ステーションコンファレンス)
    • Related Report
      2013 Final Research Report
  • [Presentation] 後発頸部リンパ節転移をCT perfusionとUS elastographyを用いて評価した舌癌の1例2012

    • Author(s)
      林孝文,斎藤美紀子,勝良剛詞,山崎学,丸山智,芳澤享子,小林正治
    • Organizer
      第30回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      さいたま市(大宮ソニックシティー)
    • Related Report
      2013 Final Research Report
  • [Presentation] 潜在的頸部リンパ節転移への CT perfusionの応用2012

    • Author(s)
      林 孝文,池真樹子,新国 農,斎藤美紀子,小山純市,田中 礼,勝良剛詞,西山秀昌
    • Organizer
      第53回日本歯科放射線学会学術大会
    • Place of Presentation
      岩手県盛岡市(岩手県民情報交流センター)
    • Related Report
      2012 Research-status Report
  • [Presentation] 後発頸部リンパ節転移をCT perfusionとUS elastographyを用いて評価した舌癌の1例2012

    • Author(s)
      林 孝文,斎藤美紀子,勝良剛詞,山崎 学,丸山 智,芳澤享子,小林正治
    • Organizer
      第30回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      大宮ソニックシティー,さいたま市
    • Related Report
      2011 Research-status Report
  • [Presentation] CT perfusionとUS elastographyにより後発頸部リンパ節転移を評価した舌癌の1例2012

    • Author(s)
      林 孝文
    • Organizer
      第31回日本画像医学会
    • Place of Presentation
      東京ステーションコンファレンス,東京
    • Related Report
      2011 Research-status Report
  • [Presentation] CT perfusionとelastographyを用いて後発頸部リンパ節転移を評価した舌癌の1例2011

    • Author(s)
      林孝文,池真樹子,新国農,斎藤美紀子,小山純市,田中礼,勝良剛詞,西山秀昌,山崎学,丸山智,芳澤享子,小林正治
    • Organizer
      第109回新潟臨床放射線学会
    • Place of Presentation
      新潟市(新潟大学医学部)
    • Year and Date
      2011-12-10
    • Related Report
      2013 Final Research Report
  • [Presentation] CT perfusionと elastographyを用いて後発頸部リンパ節転移を評価した舌癌の1例2011

    • Author(s)
      林 孝文,池真樹子,新国 農,斎藤美紀子,小山純市,田中 礼,勝良剛詞,西山秀昌,山崎 学,丸山 智,芳澤享子,小林正治
    • Organizer
      第109回新潟臨床放射線学会
    • Place of Presentation
      新潟大学医学部,新潟市
    • Related Report
      2011 Research-status Report
  • [Book] Oral Cancer ---Diagnosis and Therapy---2014

    • Author(s)
      Tadaaki Kirita and Ken Omura ed
    • Total Pages
      300
    • Publisher
      Springer Japan(発刊予定)
    • Related Report
      2013 Final Research Report
  • [Book] Oral Cancer - Diagnosis and Therapy2014

    • Author(s)
      Tadaaki Kirita and Ken Omura ed.
    • Total Pages
      300
    • Publisher
      Springer Japan
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-04   Modified: 2019-07-29  

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