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Establishment of the assessment method of salivery function by perfusion/diffusion MR imaging without using contrast agent.

Research Project

Project/Area Number 23592772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNagasaki University

Principal Investigator

SASAKI Miho  長崎大学, 大学病院, 助教 (10437874)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takashi  長崎大学, 医歯(薬)学総合研究科, 教授 (30172406)
SUMI Misa  長崎大学, 医歯(薬)学総合研究科, 准教授 (90284702)
KIMURA Yasuo  長崎大学, 医歯(薬)学総合研究科, 助教 (30253686)
EIDA Sato  長崎大学, 医歯(薬)学総合研究科, 助教 (80325662)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMRI / 灌流 / 拡散 / 唾液腺機能 / MRI / IVIM / MRI / 拡散強調撮像
Research Abstract

The aim of this study is to establish the new evaluation technique for the assessment of salivary gland perfusion and diffusion function using diffusion weighted MR imaging. Various diffusion weighted MR imaging parameters were tested, such as b-values, TRs and TEs, number of acquisition. We could achieve the imaging time within 10sec, which was enough to evaluating the salivary function before and after gustatory stimulation. We also established the head fixing gear and gustatory stimulation appliance. Healthy volunteer study revealed the good performance of this newly established method.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Intravoxel incoherent motion imaging of masticatory muscles : A pilot study for the assessment of perfusion and diffusion during clenching2013

    • Author(s)
      Sasaki M, Sumi M, Nakamura T
    • Journal Title

      AJR Am J Roentogenol

      Volume: 201(5) Pages: 1101-1107

    • Related Report
      2013 Final Research Report
  • [Journal Article] Head and neck tumours : combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types2013

    • Author(s)
      Sumi M, Nakamura T
    • Journal Title

      Eur Radiol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] IgG4-related Mikulicz's disease : Ultrasonography of the salivary and lacrimal glands for monitoring the efficacy of corticoid therapy2013

    • Author(s)
      Takagi Y, Nakamura H, Origuchi T, Miyashita T, Kawakami A, Sumi M, Nakamura T
    • Journal Title

      Clin Exp Rheumatol

      Volume: 31(5) Pages: 773-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multiparametric MR imaging for differentiating between benign and malignant thyroid nodules : initial experience in 23 patients2013

    • Author(s)
      Sasaki M, Sumi M, Kaneko K, Ishimaru K, Takahashi H, Nakamura T
    • Journal Title

      J Magn Reson Imaging

      Volume: 38 Pages: 64-71

    • Related Report
      2013 Final Research Report
  • [Journal Article] Head and neck tumors : assessment of perfusion-related parameters and diffusion coefficients based on the intravoxel incoherent motion model2013

    • Author(s)
      Sumi M, Nakamura T
    • Journal Title

      AJR Am J Roentogenol

      Volume: 34(2) Pages: 410-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Intravoxel Incoherent Motion Imaging of Masticatory Muscles: Pilot Study for the Assessment of Perfusion and Diffusion During Clenching2013

    • Author(s)
      Miho Sasaki, Misa Sumi, Marc Van Cauteren, Makoto Obara, Takashi Nakamura
    • Journal Title

      American Journal of Roentgenology

      Volume: 201 (5) Issue: 5 Pages: 1101-1107

    • DOI

      10.2214/ajr.12.9729

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between ultrasonography and MR imaging for discriminating squamous cell carcinoma nodes with extranodal spread in the neck2012

    • Author(s)
      Katayama I, Sasaki M, Kimura Y, Hotokezaka Y, Eida S, Tashiro S, Sumi M, Nakamura T
    • Journal Title

      Eur J Radiolo

      Volume: 81 Pages: 3326-31

    • Related Report
      2013 Final Research Report
  • [Journal Article] Salivary gland tumors : use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors2012

    • Author(s)
      Sumi M, Van Cauteren M, Sumi T, Obara M, Ichikawa Y, Nakamura T
    • Journal Title

      Radiology

      Volume: 263(3) Pages: 770-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Efficacy of diffusion-weighted imaging for the differentiation between lymphomas and carcinomas of the nasopharynx and oropharynx : correlations of apparent diffusion coefficients and histologic features2012

    • Author(s)
      Ichikawa Y, Sumi M, Sasaki M, Sumi T, Nakamura T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 33 Pages: 761-66

    • Related Report
      2013 Final Research Report
  • [Journal Article] Apparent diffusion coefficient- based differentiation of cystic lesions of the mandible2012

    • Author(s)
      Eida S, Hotokezaka Y, Katayama I, Ichikawa Y, Tashiro S, Sumi T, Sumi M, Nakamura T
    • Journal Title

      Oral Radiol

      Volume: 28(2) Pages: 109-14

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multiparametric MR imaging of sinonasal diseases : time-signal intensity curve- and apparent diffusion coefficient-based differentiation between benign and malignant lesions2011

    • Author(s)
      Sasaki M, Sumi M, Eida S, Ichikawa Y, Sumi T, Yamada T, Nakamura T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 32 Pages: 2154-59

    • Related Report
      2013 Final Research Report
  • [Journal Article] Apparent diffusion coefficient mapping for sinonasal diseases : Differentiation of benign and malignant lesions2011

    • Author(s)
      Sasaki M, Eida S, Sumi M, Nakamura T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 32 Pages: 1100-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Magnetic resonance imaging-based differentiation between juvenile recurrent parotitis and juvenile Sjögren's syndrome2011

    • Author(s)
      Kimura Y, Hotokezaka Y, Sasaki M, Takagi Y, Eida S, Katayama I, Sumi M, Nakamura T
    • Journal Title

      Oral Radiol

      Volume: 27 Pages: 73-77

    • Related Report
      2013 Final Research Report
  • [Journal Article] Extranodal spread in the neck : MRI detection on the basis of pixel-based time-signal intensity curve analysis2011

    • Author(s)
      Sumi M, Nakamura T
    • Journal Title

      J Magn Reson Imaging

      Volume: 33(4) Pages: 830-8

    • Related Report
      2013 Final Research Report
  • [Presentation] In Vitro Measurement Of Apoptotic And Non-apopttic Cells Using Diffusion- Weighted MR2013

    • Author(s)
      Yuka hotokezaka, Sato Eida, Ikuo Katayama, Miho Sasaki, Misa Sumi, Takashi Nakamura
    • Organizer
      19th International Congress of the IADMFR
    • Place of Presentation
      Bergen (Norway)
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 簡便なIntravoxel incoherent motion (IVIM)パラメータの計算法について2013

    • Author(s)
      佐々木美穗、角美佐、中村卓
    • Organizer
      日本歯科放射線学会第54回学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] Differentiation Between Apoptotic and Non-Apoptotic Cell Death Using Diffusion-Weighted MR2013

    • Author(s)
      Sato Eida, Marc Van Cauteren, Yuka Hotokezaka, Makoto Obara, Tomoaki Okuaki, Ikuo Katayama, Miho Sasaki, Misa Sumi, and Takashi Nakamura
    • Organizer
      21^<st> Annual Meeting of International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Salt Lake(USA)
    • Related Report
      2013 Final Research Report
  • [Presentation] 簡便なIntravoxel incoherent motion (IVIM)パラメータの計算法について2013

    • Author(s)
      佐々木美穗、角 美佐、中村 卓
    • Organizer
      NPO法人日本歯科放射線学会第54回総会・学術大会
    • Place of Presentation
      福岡県福岡市早良区百道2-3-1 ももちパレス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部腫瘍性病変にDWIおよびDCET1WIを応用し得られる血流情報について2012

    • Author(s)
      角美佐、市川陽子、高木幸則、榮田智、木村泰男、佐々木美穂、中村卓
    • Organizer
      日本歯科放射線学会第17回臨床画像大会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Final Research Report
  • [Presentation] 咀嚼筋のIVIM MRイメージング2012

    • Author(s)
      佐々木美穗、角美佐、中村卓
    • Organizer
      日本歯科放射線学会第53回学術大会
    • Place of Presentation
      盛岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 咀嚼筋のIVIM MRイメージング2012

    • Author(s)
      佐々木美穂、角美佐、中村卓
    • Organizer
      第53回日本歯科放射線学会総会
    • Place of Presentation
      岩手県盛岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] Intravoxel incoherent motion (IVIM) MRIの唾液腺腫瘍への応用2011

    • Author(s)
      角美佐、佐々木美穂、角忠輝、木村泰男、高木幸則、榮田智、市川陽子、中村卓
    • Organizer
      日本歯科放射線学会第16回臨床画像大会
    • Place of Presentation
      新潟市
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.nagasaki-u.ac.jp

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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