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Mechanism of gingival overgrowth caused by medication - Expression and role of ets transcription factor -

Research Project

Project/Area Number 23592779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNihon University

Principal Investigator

MATSUMOTO Hiroko  日本大学, 松戸歯学部, 講師 (50221594)

Co-Investigator(Kenkyū-buntansha) AKIMOTO Yoshiaki  日本大学, 松戸歯学部, 教授 (10147720)
ONO Makiko  日本大学, 松戸歯学部, 助手 (00267113)
TAKEUCHI Reiri  日本大学, 松戸歯学部, 助手 (60419778)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords歯肉肥厚 / 細胞増殖 / 細胞周期 / ets-1 / フェニトイン / Ets遺伝子 / IL-1α / 転写因子 / 薬物性歯肉肥厚 / ets遺伝子 / 炎症性因子
Research Abstract

IL-1a increased phosphorylations of ERK, p38 MAPK, and HSP27, and expression of Ets-1 in human gingival fibroblasts. The inhibition of G1 cell cycle arrest in human gingival fibroblasts may result from an increase in phosphorylated Cdk2 and Rb proteins and decreased levels of p21 and p27 proteins by phenytoin. Because the phosphorylation of Ets-1 is controlled by cyclin, it is suggested that expressions of Ets-1 and ESE-3 by IL-1a is associated with gingival overgrowth.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Inhibition of G1 Cell Cycle Arrest in Human Gingival Fibroblasts Exposed to Phenytoin2012

    • Author(s)
      Reiri Takeuchi,Hiroko Matsumoto, Yoshiaki Akimoto,Akira Fujii
    • Journal Title

      Fundam Clin Pharmacol

      Volume: 2012 Issue: 1 Pages: 1-6

    • DOI

      10.1111/j.1472-8206.2012.01065.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Inhibitory, Action of Amlodipine for TNF-α-induced Apopto- sis in Cultured Human Gingival Fibro- blasts2012

    • Author(s)
      Takeuchi R,Matsumoto H,Akimoto Y,Fujii A
    • Journal Title

      歯科薬物療法

      Volume: 31(2) Pages: 45-52

    • NAID

      10031168920

    • URL

      https://www.jstage.jst.go.jp/browse/jsotp/31/2/_contents/-char/ja

    • Related Report
      2013 Final Research Report
  • [Journal Article] The Inhibitory Action of Amlodipine for TNF-α-induced Apoptosis in Cultured Human Gingival Fibroblasts2012

    • Author(s)
      Reiri Takeuchi,Hiroko Matsumoto, Yoshiaki Akimoto,Akira Fujii
    • Journal Title

      Oral Therap Pharmacol

      Volume: 31(2) Pages: 45-52

    • NAID

      10031168920

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 18-alpha- glycyrrhetinic acid suppresses G1/S- phase transition and induces apoptosis in gingival fibroblast isolated from a patient that presented with nifedi- pine-induced gingival overgrowth2014

    • Author(s)
      Takeuchi R, Ono M, Arikawa K, Akimoto Y, Fujii A, Matsumoto H
    • Organizer
      17th World Congress on Basic & Clinical Pharmacology
    • Place of Presentation
      Cape Town International Convention Center (Cape Town)
    • Year and Date
      2014-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of phenytoin on caspase activity in cultured human gingival fibroblasts2014

    • Author(s)
      Takeuchi R, Ono M, Akimoto Y, Fujii A, Matsumoto H
    • Organizer
      第34回日本歯科薬物療法学会
    • Place of Presentation
      大阪歯科大学(大阪)
    • Year and Date
      2014-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of phenytoin on caspase activity in cultured human gingival fibroblasts2014

    • Author(s)
      Reiri Takeuchi, Makiko Ono, Yoshiaki Akimoto, Akira Fujii, Hiroko Matsumoto
    • Organizer
      第34回日本歯科薬物療法学会
    • Place of Presentation
      大阪歯科大学創立100周年記念館(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 18-alpha-glycyrrhetinic acid suppresses G1/S-phase transition and induces apoptosis in gingival fibroblast isolated from a patient that presented with nifedipine-induced gingival overgrowth2014

    • Author(s)
      Reiri Takeuchi, Makiko Ono, Kazumune Arikawa, Yoshiaki Akimoto, Akira Fujii, Hiroko Matsumoto
    • Organizer
      17th World Congress on Basic & Clinical Pharmacology
    • Place of Presentation
      Cape Town International Convention Centre (Cape Town)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tentative Pharmaco- therapy for Nifedipine-induced Gin- gival Overgrowth using 18α-glycyr- rhetinic Acid2013

    • Author(s)
      Takeuchi R, Ono M, Akimoto Y, Fujii A, Matsumoto H
    • Organizer
      第33回日本歯科薬物療法学会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Tentative Pharmacotherapy for Nifedipine-induced Gingival Overgrowth using 18α-glycyrrhetinic Acid2013

    • Author(s)
      Reiri Takeuchi, Makiko Ono, Yoshiaki Akimoto, Akira Fujii, Hiroko Matsumoto
    • Organizer
      第33回日本歯科薬物療法学会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Mechanism of Phenytoin-induced Gingival Overgrowth2012

    • Author(s)
      Reiri Takeuchi,Hiroko Matsumoto, Yoshiaki Akimoto,Akira Fujii
    • Organizer
      第32回日本歯科薬物療法学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] The Mechanism of Nifedipine- induced Gingival Overgrowth2011

    • Author(s)
      Takeuchi R, Matsumoto H, Akimoto Y, Fujii A
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] アムロジピンによる歯肉肥厚の発症機序2011

    • Author(s)
      松本裕子,竹内麗理,小野眞紀子,秋元芳明,藤井彰
    • Organizer
      第13回応用薬理シンポジウム
    • Place of Presentation
      日本大学薬学部(船橋)
    • Year and Date
      2011-09-04
    • Related Report
      2013 Final Research Report
  • [Presentation] The Mechanism of Phenytoin- induced Gingival Overgrowth2011

    • Author(s)
      Takeuchi R, Matsumoto H, Akimoto Y, Fujii A
    • Organizer
      第32回日本歯科薬物療法学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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