| Project/Area Number |
23592781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
TOMOKO NASHIDA 日本歯科大学, 新潟生命歯学部, 准教授 (10133464)
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Akane 日本歯科大学, 新潟生命歯学部, 准教授 (60180080)
YOSHIE Sumio 日本歯科大学, 新潟生命歯学部, 教授 (30095278)
SHIMOMURA Hiromi 日本歯科大学, 新潟生命歯学部, 教授 (40139259)
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| Co-Investigator(Renkei-kenkyūsha) |
HAGA Maiko (TSUJIMURA Maiko) 日本歯科大学, 新潟生命歯学部, 講師 (60535219)
SATO Ritsuko 日本歯科大学, 新潟短期大学, 准教授 (50178787)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アクアポリン / シェーグレン症候群 / マウス / 耳下腺 / 腺房細胞 / アクアポリン５ / NODマウス / 局在性 / 輸送タンパク質 / 口腔乾燥症 / 細胞内輸送 / cDNAマイクロアレイ |
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| Research Abstract |
1. The protein which co-localizes with aquaporin 5 was determined. Localization of these proteins was changed in the diabetic NOD mice. 2. Three spots of aquaporin 5 with different isoelectric points were determined.The main spot in the control mouse was detected at pI 6.0, and that in the diabetic NOD mouse was at pI 8.8 which coincides with the isoelectric point of aquaporin 5 without phosphorylation. This indicated that the phosphorylation level of aquaporin 5 was lower in the diabetic NOD mouse.
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