| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
T cells play a key role in inflammation through their ability to migrate into connective tissues. CXCL12 is one of the chemokines that promote leukocytes invasion and migration into tissues, while the exact molecular mechanisms are not clear at present. In this study, we showed that CXCL12 significantly enhances CD4+human jurkat T cells invasion into type I collagen by the catalytic activity of MMP-1. siRNA STAT blocked CXCL12 enhanced invasion into type I collagen on jurkat T cells. STAT localized in nuclear in CXCL12 stimulated jurkat T cells. We suggest that STAT regulated the production of MMPs and invasion into type I collagen on T cells.
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