The mechanism of T cell invasion in chronic periodontities
| Project/Area Number |
23592786
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka Dental University |
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Principal Investigator |
GODA Seiji 大阪歯科大学, 歯学部, 講師 (70351476)
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| Co-Investigator(Kenkyū-buntansha) |
KANESHITA Yuki 大阪歯科大学, 歯学部, 講師(非常勤) (70595793)
IKEO Takashi 大阪歯科大学, 歯学部, 教授 (40159603)
DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
DOMAE Eisuke 大阪歯科大学, 歯学部, 助教 (50454559)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | T細胞 / ケモカイン / I型コラーゲン |
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| Research Abstract |
T cells play a key role in inflammation through their ability to migrate into connective tissues. CXCL12 is one of the chemokines that promote leukocytes invasion and migration into tissues, while the exact molecular mechanisms are not clear at present. In this study, we showed that CXCL12 significantly enhances CD4+human jurkat T cells invasion into type I collagen by the catalytic activity of MMP-1. siRNA STAT blocked CXCL12 enhanced invasion into type I collagen on jurkat T cells. STAT localized in nuclear in CXCL12 stimulated jurkat T cells. We suggest that STAT regulated the production of MMPs and invasion into type I collagen on T cells.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] The Effect of lysenin on the differentiation into osteoclast cells2011
Author(s)
Domae E, Ogawa Y, Takeuchi O, Ujii Y, Kato Y, Kawasaki T, Hayashi H, Komasa R, Domae N, Goda S, Ikeo T
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Journal Title
J Oral Tissue Engin
Volume: 9巻
Pages: 3-9
NAID
Related Report
Peer Reviewed
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[Presentation] PDGF-bbはヒト歯肉由来線維芽細胞においてMMP-1産生を増強する2011
Author(s)
川崎俊也,合田征司,竹内摂,氏井庸介,林寛,小正玲子,加藤侑,林宏行,山本一世,池尾隆,松本尚之
Organizer
第9回日本再生歯科医学会学術大会・総会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2011-09-10
Related Report
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[Presentation] 歯根膜細胞においてVDR発現が破骨細胞分化因子を調節する2011
Author(s)
吉川美弘,川本章代,新原拓也,竹山旭,堂前英資,合田征司,田村功,鎌田愛子,森田章介,岡崎定司,小正裕,池尾隆
Organizer
第9回日本再生歯科医学会学術大会・総会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2011-09-10
Related Report
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