| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Oral Biofilms, unlike those formed at most other sites in the human body, are unique because surgical intervention is usually unnecessary for their removal. The control of oral biofilms relies mainly on mechanical elimination. A wide range of antimicrobial agents have been formulated into oral care products in order to enhance the effect of the mechanical plaque control. It is proven that the chemical control using antimicrobial compounds provides some antimicrobial benefit and improves the clinical parameters.
However, some reports have demonstrated that antimicrobial compounds do not effect as they are intended because of physiological heterogeneity in biofilms.
This project aimed to develop new strategies for the control of mature oral biofilms targeting to the matrices.
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