| Project/Area Number |
23592803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
鷲尾 絢子 九州歯科大学, 歯学部, 助教 (10582786)
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| Co-Investigator(Renkei-kenkyūsha) |
WASHIO Ayako 九州歯科大学, 歯学部, 助教 (10582786)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 歯髄 / 根尖歯周組織 / 象牙芽細胞 / 骨芽細胞 / 再生医療 / 骨 / 炎症制御 / 慢性炎症 |
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| Research Abstract |
To develop dual induction therapy for the regulation of chronic inflammation and hard tissue formation of dental pulp and periapical tissues, we focused on effects of newly developed cement on several cells, effects of steroid coactivator MTI-II on osteoblasts, effects of PRP and BMP-2 on odontoblasts, and effects of ameloblastin on epithelial cells. We found that the biocompatibility of newly developed cement, effects of BMP-2 on odontoblast differentiation, the suppression of epithelial cell proliferation by ameloblastin, the regulation of inflammatory responses of osteoblasts by MTI-II, and the induction of odontoblast differentiation related molecules by PRP.
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