| Project/Area Number |
23592805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Hiroaki 奥羽大学, 歯学部, 講師 (10265209)
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|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 光増感剤 / 根管治療 / ナノ粒子 / 細菌検査 / レーザー / 臨床診断 / 蛍光色素 / 歯内療法 |
|---|
| Research Abstract |
Methylene blue as a photosensitizer, and poly (lactic-co-glycolic acid) (PLGA) spherical nanoparticles loaded with chitosan (particle size 250 nm) were used to combine microbe in this study. DIAGNOdent laser device (wavelength 655 nm) was used to detect photosensitizer with nanoparticles combined to microbe, and this study was performed within the nanoparticles concentration range of 0.01, 0.1, 1, 10 mg/ml. Detection sensitivity was slight increased using methylene blue-coated PLGA nanoparticles, but some problems still remain to complete diagnosis.
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