| Project/Area Number |
23592818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroshi 愛知学院大学, 歯学部, 教授 (40064878)
OZEKI Nobuaki 愛知学院大学, 歯学部, 講師 (70469005)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | ポリリン酸 / 医療用材料 / 歯髄細胞 / 象牙芽細胞 / マトリックスメタロプロテアーゼ（MMP） / 象牙質シアロリンタンパク（DSPP） / アポトーシス / PolyP / ポリリン酸ナトリウム / sodium polyphosphate / ＭＭＰ |
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| Research Abstract |
For the past decade, it has been found that polyphosphoric acid used widely as a food additive affects the bioactivity of various cells. Therefore, for the development of new medical materials using the polyphosphoric acid, we examined effects of the sodium polyphosphate (Poly-P) on the proliferation and differentiation of dental pulp (DP) cells. As a result, Poly-P significantly accelerated the proliferation of DP cells and induced their differentiation into odontoblasts with low concentration. Our current data suggests that matrix metalloproteinase (MMP) -3 induced by Poly-P may be involved in the cell proliferation.
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