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Development of new bone filling materials using Sr-containing bioactive glasses

Research Project

Project/Area Number 23592821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

IZUMI Toshio  福岡歯科大学, 歯学部, 准教授 (40248547)

Co-Investigator(Kenkyū-buntansha) ANAN Hisashi  福岡歯科大学, 口腔歯学部, 教授 (80158732)
Co-Investigator(Renkei-kenkyūsha) MATSUYA Shigeki  福岡歯科大学, 口腔歯学部, 教授 (00108755)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords生体活性ガラス / ストロンチウム / ポリグルタミン酸 / 骨補填材
Research Abstract

Strontium (Sr) that has been proved to promote bone formation in vivo is used as an anti-osteoporotic oral drug. The bioactive glass can bond chemically to bone through formation of bone-like hydroxyapatite layer on its surface, and is used as a bone substitute material. We prepared trial products of Sr-containing bioactive glass particles, and it was suggested that they could promote bone regeneration in rat calvarial defects. There may be an association with the controlled release of Sr to the bone tissue, which occured by dissolution of the glass particles.
Hardened cement pastes were made by mixing acid and the Sr-containing glass particles in order to fill densely the rat calvarial defects. When polyglutamic acid was used, a cement paste was easy to flow out of the defects, but it was suggested that the paste should promote formation of new bone.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012 Other

All Presentation (6 results)

  • [Presentation] Sr含有試作生体活性ガラスの骨形成能の病理組織学的検討2014

    • Author(s)
      泉利雄, 板家圭祐, 水上正彦, 中山英明, 松本典祥, 畠山純子, 阿南壽
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      滋賀
    • Year and Date
      2014-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Sr含有生体活性ガラスの骨形成能の病理組織学的検索2014

    • Author(s)
      板家圭祐、泉 利雄、水上正彦、松本典祥、畠山純子、中山英明、阿南 壽
    • Organizer
      日本歯科保存学会学2014年度春季術大会(140回)
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストロンチウム置換生体活性ガラスはin vitroにおいて象牙芽細胞様株細胞の分化を促進する2013

    • Author(s)
      諸冨孝彦, 北村知昭, 泉利雄, 水上正彦, 西崎竜司, 稲永晃子, 阿南壽
    • Organizer
      日本歯科保存学会学
    • Place of Presentation
      秋田
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] ストロンチウム置換生体活性ガラスはin vitroにおいて象牙芽細胞様株細胞の分化を促進する2013

    • Author(s)
      諸冨 孝彦、北村 知昭、泉 利雄、水上 正彦、西崎 竜司、稲永 晃子、阿南 壽
    • Organizer
      日本歯科保存学会学2013年度秋季術大会(139回)
    • Place of Presentation
      秋田市中通
    • Related Report
      2013 Annual Research Report
  • [Presentation] Strontium含有試作Bioactive glassの生体親和性2012

    • Author(s)
      泉利雄, 福田泰子, 板家圭祐, 春名千英子, 松本典祥, 諸冨孝彦, 阿南壽
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Strontium含有試作Bioactive glassの生体親和性

    • Author(s)
      泉利雄、福田泰子、板家圭祐、春名千英子、松本典祥、諸冨孝彦、阿南壽
    • Organizer
      歯科保存学会2012年度秋季学術大会
    • Place of Presentation
      広島市 広島国際会議場
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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