Bone formation of stressed cells under bio-mimetic condition
| Project/Area Number |
23592824
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthetic dentistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
IIDA Shunji 北海道大学, 大学病院, 講師 (30281827)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKAZAWA Toshiyuki 北海道立総合研究機構, 産業技術研究本部, 研究主幹 (80469692)
YOKOYAMA Atsuro 北海道大学, 大学院歯学研究科, 教授 (20210627)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 骨形成 / 骨芽細胞 / メカニカルストレス / ハイドロキシアパタイト / コラーゲン / 骨芽細胞様細胞 |
|---|
| Research Abstract |
As a preliminary experiment, we investigated the effect of ultrasonic treatment for hydroxyapatite ceramics to the cell adhesion. Due to ultrasonic treatment at the surface of hydroxyapatite ceramics, a plenty of micro pores and micro cracks were observed and the increasing cell numbers raised the ability of cell adhesion to the ceramics.
Osteoblastic cell culturing under the biomimetic condition caused cells extended the process three dimensionally on collagen gel. And Cells increased osteocalcin expression against mechanical stress by hydroxyl apatite block.
|
Report
(4 results)
Research Products
(15 results)
