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Development of diagnostic method of osteoporosis using the structural indices of mandibular alveolar bone.

Research Project

Project/Area Number 23592839
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthetic dentistry
Research InstitutionNiigata University

Principal Investigator

TANAKA MIKAKO  新潟大学, 医歯学総合病院, 講師 (20361909)

Co-Investigator(Kenkyū-buntansha) EJIRI Sadakazu  朝日大学, 歯学部, 教授 (40160361)
IDA Hiroko  新潟大学, 医歯学系, 准教授 (60293213)
TANAKA Rei  新潟大学, 医歯学総合病院, 助教 (30323992)
YAMADA Kazuho  新潟大学, 医歯学総合病院, 助教 (20397152)
NOMURA Shuichi  新潟大学, 医歯学系, 教授 (40018859)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Naoki  新潟大学, 医歯学系, 助教 (50251830)
YAMAMOTO Noriaki  新潟医療福祉大学, 骨の科学研究所, 転倒予防センター所長 (30445902)
HAYASHI Takafumi  新潟大学, 医歯学系, 教授 (80198845)
Research Collaborator MIKAMI Emi  
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords骨粗鬆症 / 下顎骨 / 微細骨梁構造 / 歯科用コーンビームCT / 骨形態計測 / 骨代謝マーカー / 踵骨骨密度 / 歯科用コーンビームCT / 三次元骨形態計測 / 歯槽骨 / 骨梁構造 / マイクロCT / 頸椎 / 下顎
Outline of Final Research Achievements

The uni-lateral mandibles of ten elderly women were scanned using the dental cone beam CT device. The structural model index (SMI) and the star volume of mandibles showed significant relationships to the calcaneal bone density which was measured using Speed of Sound (SOS) with an ultrasound device. The node number (N.Nd) and the terminus number (N.Tm) as well as the bone surface (BS/TV) (%), trabecular number (Tb.N), and trabecular spacing (Tb. Spac) of mandibles significantly related to one of bone turnover markers, TRACP-5b. The present study therefore revealed changes in alveolar cancellous bone structure of elderly women, and also that this structure varies in relationship to the calcaneal bone density and some of bone turnover markers.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Microstructural observation with microCT and histological analysis of human alveolar bone biopsy from a planned implant site: A case report.2013

    • Author(s)
      Yamashita-Mikami E1, Tanaka M, Sakurai N, Yamada K, Ohshima H, Nomura S, Ejiri S.
    • Journal Title

      Open Dent J

      Volume: 7 Issue: 1 Pages: 47-54

    • DOI

      10.2174/1874210601307010047

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microstructural observation with microCT and histological analysis of human alveolar bone biopsy from a planned implant site: A case report.2013

    • Author(s)
      Yamashita-Mikami E, Tanaka M, Sakurai N, Yamada K, Ohshima H, Nomura S, Ejiri S
    • Journal Title

      Open Dent J

      Volume: 8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト抜歯窩治癒過程における歯槽骨の骨梁構造・骨塩量の変化2013

    • Author(s)
      田中みか子,三上絵美 ,櫻井直樹,芳澤享子 ,山田一穂 , 船山昭典,三上俊彦 ,野村修一 ,江尻貞一
    • Organizer
      第33回日本骨形態計測学会
    • Place of Presentation
      浜松市 アクトシティ浜松コングレスセンター
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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