Causes of the delay in efficacies of oral care during chronic phase

• Project/Area Number: 23592853
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KASHIWABARA Toshiya 徳島大学, 大学病院, 助教 (90274232)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Tetsuo 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (90193432) ; NAGAO Kan 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (30227988)
• Co-Investigator(Renkei-kenkyūsha): HIROTA Katsuhiko 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (60199130)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 高齢者 / 誤嚥性肺炎 / 口腔ケア / 口腔刺激 / 免疫 / 慢性期 / 光トポグラフィー / 効果の遅延 / miRNA

Research Abstract

The purpose of this study is to clarify why the efficacies of oral care is delayed in the chronic phase, to re-recognize the significance of oral care, to explore effective oral care methods. The following research has been done: literature review, measurements of the cerebral blood flow in the prefrontal cortex using a light topography (NIRS), the effect of oral stimulation on the immune function and behavior patterns (Induction of anxious feeling) in mice, and the development of simple oral care evaluation method. As a result, it could be found to impact on the activity of brain function by the stimulation into the oral cavity compared to that into the other site, but little effect on immune function was found. It is suggested that the delay, conversely the effect, would be multifactorially caused.

Research Products

• [Journal Article] Effects of extracellular DNA from Candida albicans and pneumonia-related pathogens on Candida biofilm formation and hyphal transformation (2014)
  • Author(s): Sapaar B, Nur A, Hirota K, Yumoto H, Murakami K, Amoh T, Matsuo T, Ichikawa T, Miyake Y.
  • Journal Title: J Appl Microbiol Volume: - Issue: 6 Pages: 1531-1542
  • DOI: 10.1111/jam.12483
  • Peer Reviewed
• [Journal Article] In vitro カンジダバイオフィルムに対する電解次亜水の効果 (2014)
  • Author(s): 柏原 稔也, 米山 武義, 中道 敦子, 本田 剛, 東岡 紗知江, 後藤 崇晴, 永尾 寛, 市川 哲雄
  • Journal Title: 老年歯科医学 Volume: Vol. 28 ( No. 3) Pages: 277-283
  • NAID: 130004835462
  • Peer Reviewed
• [Journal Article] In vitroカンジダバイオフィルムに対する電解次亜水の効果 (2013)
  • Author(s): 柏原稔也, 米山武義, 中道敦子, 本田剛, 東岡紗知江, 後藤崇晴, 永尾寛, 市川哲雄
  • Journal Title: 老年歯科医学 Volume: 28巻, 3号(0914-3866) Pages: 277-283
  • NAID: 130004835462
  • Peer Reviewed
• [Journal Article] 口腔ケアと歯科医療デバイス (2012)
  • Author(s): 東岡紗知江, 本釜聖子, 本田剛, 柏原稔也, 永尾寛, 市川哲雄
  • Journal Title: 四国歯学会雑誌 Volume: 24巻, 2号 Pages: 35-37
  • NAID: 120005832465
• [Journal Article] Main occluding area in partially edentulous patients : changes before and after implant treatment (2012)
  • Author(s): Goto T, Nishinaka H, Kashiwabara T, Nagao K, Ichikawa T.
  • Journal Title: J Oral Rehabil Volume: 39(9) Pages: 677-683
  • Peer Reviewed
• [Journal Article] Biofilm formation of Candida albicans on implant overdenture materials and its removal (2012)
  • Author(s): Li J, Hirota K, Goto T, Yumoto H, Miyake Y, Ichikawa T.
  • Journal Title: J Dent Volume: 40(8) Issue: 8 Pages: 686-692
  • DOI: 10.1016/j.jdent.2012.04.026
  • Peer Reviewed
• [Journal Article] 口腔ケアと歯科医療デバイス (2012)
  • Author(s): 東岡紗知江
  • Journal Title: 四国歯学会雑誌 Volume: 24(2) Pages: 35-37
  • Peer Reviewed
• [Presentation] 口腔内刺激が脳機能活動に与える影響 (2013)
  • Author(s): 檜垣宣明, 後藤崇晴, 石田雄一, 友竹偉則, 永尾寛, 市川哲雄, 多田望
  • Organizer: 平成25年度公益社団法人日本補綴歯科学会中国・四国支部学術大会
  • Place of Presentation: 総合あんしんセンター(高知県)
  • Year and Date: 2013-08-31
• [Presentation] 多チャンネルセンサを用いた嚥下音記録による嚥下動態評価 (2013)
  • Author(s): 本田剛, 比嘉仁志, 東岡紗知江, 本釜聖子, 永尾寛, 市川哲雄
  • Organizer: 日本老年歯科医学会第24回学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2013-06-06
• [Presentation] スダチのにおい刺激による咀嚼嚥下促進補助法の開発 : 刺激剤と刺激方法の検討 (2013)
  • Author(s): 東岡紗知江, 比嘉仁志, 本田剛, 本釜聖子, 永尾寛, 市川哲雄
  • Organizer: 日本老年歯科医学会第24回学術大会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2013-06-05
• [Presentation] in vitroカンジダバイオフィルムに対する電解次亜水の効果 (2013)
  • Author(s): 柏原稔也, 米山武義, 市川哲雄
  • Organizer: 日本口腔機能水学会第14回学術大会
  • Place of Presentation: 北海道歯科医師会館(北海道)
  • Year and Date: 2013-03-24
• [Presentation] ルミテスターを用いた義歯の超音波洗浄効果の評価 (2013)
  • Author(s): 本田剛, 後藤崇晴, 内藤禎人, 柏原稔也, 市川哲雄
  • Organizer: 第5回日本義歯ケア学会学術大会
  • Place of Presentation: 大阪歯科大学附属病院(大阪府)
  • Year and Date: 2013-01-27
• [Presentation] Efficiency of oral stimulations on brain function activities : Evaluations using wearable near-infrared spectroscopy (2013)
  • Author(s): Higaki N, Goto T, Iwawaki Y, Nagao K, Ichikawa T.
  • Organizer: The 15th Biennial Meeting of International College of prosthodontics
  • Place of Presentation: The Lingotto Congress Centre (Italy)
• [Presentation] 機械的刺激応答性miRNAの同定 (2013)
  • Author(s): 岩脇有軌, 水澤典子, 岩田武男, 小野信二, 友竹偉則, 市川哲雄, 吉本勝彦
  • Organizer: 第5回日本RNAi研究会
  • Place of Presentation: グランドプリンスホテル広島(広島県)
• [Presentation] 口腔内刺激が脳機能活動に与える影響 (2013)
  • Author(s): 檜垣宣明，後藤崇晴，石田雄一，友竹偉則，永尾 寛，市川哲雄，多田 望
  • Organizer: 公益社団法人日本補綴歯科学会中国・四国支部学術大会
  • Place of Presentation: 総合あんしんセンター(高知県)
• [Presentation] Efficiency of oral stimulations on brain function activities: Evaluations using wearable near-infrared spectroscopy (2013)
  • Author(s): Higaki Nobuaki, Goto Takaharu, Iwawaki Yuki, Nagao Kan, Ichikawa Tetsuo
  • Organizer: 15th Biennial Meeting of International College of Prosthodontics
  • Place of Presentation: Lingotto Congress Center (Turin, Italy)