| Project/Area Number |
23592866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Akira 明海大学, 歯学部, 准教授 (70236454)
TAKANO Akiko 明海大学, 歯学部, 講師 (20337504)
FUJISAWA Masanori 明海大学, 歯学部, 教授 (00209040)
YASUI Toshikazu 明海大学, 歯学部, 教授 (20146252)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | MCP-1 / TNF-α / 骨芽細胞様細胞 / 骨芽細胞 / 歯根膜細胞 / 炎症性サイトカイン / 歯学 / ストレス / 歯根膜 |
|---|
| Outline of Final Research Achievements |
The inflammatory cytokine TNF-α is a potent osteotrophic cytokine. Although monocytes are often observed near areas undergoing bone resorption in the periodontal ligament tissue, the mechanism of monocyte recruitment is unknown. We considered that monocyte chemoattractant MCP-1 is contributed in the monocyte recruitment. It has been showed that the periodontal ligament cells have phenotypes typical of osteoblasts, and then, we examined the effect of TNF-α on expression of MCP-1 by using the osteoblastic cells. Moreover, it has been suggested a functional role of transcriptional factor AP-1 in MCP-1 gene expression induced by TNF-α. TNF-α-induced MCP-1 gene expression is suppressed by pretreatment of SP600125, a potent inhibitor for JNK. Thus, TNF-α has the ability to stimulate AP-1-mediated expression of MCP-1 after activation of JNK in osteoblastic cells.
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