| Project/Area Number |
23592876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIZAWA Tatsuya 熊本大学, 大学院生命科学研究部, 講師 (40313530)
OKAZAKI Joji 大阪歯科大学, 歯学部, 教授 (80169094)
YOSHIKAWA Yoshihiro 大阪歯科大学, 歯学部, 助教 (70434793)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ヒアルロン酸 |
|---|
| Research Abstract |
We focused on the effects of macromolecule polysaccharide, in particular, hyaluronan in periodontal tissue. As a result, the proliferation in osteoblasts was increased, and the attachment in bone marrow stromal cells was suppressed, and the number of cells stained by TRAP as a measure of osteoclast differentiation was decreased, when it cultured with hyaluronan. These findings suggest that hyaluronan is efficient in bone regeneration, and it might be applicable to a carrier for periodontal tissue regenerative.
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