| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Both the epithelial cells of Malassez and periodontal ligament fibroblasts were co-cultured in the same dish. The interactions between the epithelial cells of Malassez and periodontal ligament fibroblastscurrent induceed the expression of amelogenin, ameloblastin, MMP-20 and KLK 4 in the epithelial cells of Malassez.
We also showed that the epithelial cells of Malassez which incorporated BrdU expressed Bax strongly in co-cultured cells, suggesting that the epithelial-mesenchymal interactions enhance cell turnover in the epithelial cells of Malassez.
These results indicate that epithelial-mesenchymal interactions may induce cell turnover and cellular cementum formationin in the epithelial cells of the rests of Malassez.
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