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The study of cementum regeneration in epithelial-mesenchymal interaction

Research Project

Project/Area Number 23592880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

SHIMONISHI Mitsuru  東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40302153)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生歯学 / セメント質 / マラッセの上皮遺残 / 上皮―間葉相互作用 / cell turnover
Research Abstract

Both the epithelial cells of Malassez and periodontal ligament fibroblasts were co-cultured in the same dish. The interactions between the epithelial cells of Malassez and periodontal ligament fibroblastscurrent induceed the expression of amelogenin, ameloblastin, MMP-20 and KLK 4 in the epithelial cells of Malassez.
We also showed that the epithelial cells of Malassez which incorporated BrdU expressed Bax strongly in co-cultured cells, suggesting that the epithelial-mesenchymal interactions enhance cell turnover in the epithelial cells of Malassez.
These results indicate that epithelial-mesenchymal interactions may induce cell turnover and cellular cementum formationin in the epithelial cells of the rests of Malassez.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in the epithelial cells of the rests of Malassez in vitro2012

    • Author(s)
      Ken Takahashi, Mitsuru Shimonishi, Rui Wang,Hiroatsu Watanabe, Masahiko Kikuchi
    • Journal Title

      European Journal of Oral Science

      Volume: 120巻 Pages: 475-483

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 培養ヒト歯根膜由来上皮細胞および線維芽細胞間相互作用によるエナメルマトリックスおよびプロテアーゼの調整2012

    • Author(s)
      渡邉弘淳、下西充、高橋健、小松正志、菊池雅彦
    • Journal Title

      日本歯科保存学会誌

      Volume: 55巻 Pages: 141-150

    • NAID

      110009479990

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 培養ヒト歯根膜由来上皮細胞および線維芽細胞間相互作用によるエナメルマトリックスおよびプロテアーゼの調整2012

    • Author(s)
      渡邉 弘淳、下西 充、高橋 健、小松 正志、菊池 雅彦
    • Journal Title

      日本歯科保存学雑誌

      Volume: 55 Pages: 141-150

    • NAID

      110009479990

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in the epithelial cells of the rests of Malassez in vitro2012

    • Author(s)
      Ken Takahashi, Mitsuru Shimonishi, Rui Wang, Hiroatsu Watanabe, Masahiko Kikuchi
    • Journal Title

      European Journal of Oral Science

      Volume: 120 Issue: 6 Pages: 475-483

    • DOI

      10.1111/j.1600-0722.2012.01002.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 培養ヒト歯根膜由来上皮細胞および線維芽細胞間相互作用によるエナメルマトリックスの調整2012

    • Author(s)
      渡邉弘淳、下西 充、高橋 健、小松正志、菊池雅彦
    • Journal Title

      日本歯科保存学雑誌

      Volume: 55

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in vitro2012

    • Author(s)
      Wang R, Shimonishi M, Takahashi K, Watanabe H, Saito S, Komatsu M, Kikuchi M.
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      中国、四川
    • Related Report
      2013 Final Research Report
  • [Presentation] Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in vitro2012

    • Author(s)
      Wang R, Shimonishi M, Takahashi K, Watanabe H, Saito S, Komatsu M, Kikuchi M
    • Organizer
      2012 Sino-Japan Dental Conference
    • Place of Presentation
      中国 四川
    • Related Report
      2012 Research-status Report
  • [Presentation] 20μm チタンメッシュを用いた歯周組織再生2012

    • Author(s)
      石幡浩志,岩間張良,下西 充, 小林洋子,島内英俊
    • Organizer
      第55回春季日本歯周病学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 培養歯根膜由来上皮―間葉相互作用によるマラッセの上皮遺残細胞のアポトーシス誘導2012

    • Author(s)
      王 鋭、下西 充、遠藤 直樹、高橋 健、渡邉 弘淳、斎藤 修
    • Organizer
      第136回春季日本歯科保存学会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Presentation] 培養ヒト歯根膜由来上皮細胞および線維芽細胞間相互作用による石灰化調整2011

    • Author(s)
      高橋健、下西充、渡邉弘淳、遠藤直樹、齊藤修、小松正志
    • Organizer
      日本歯科保存学会2011年度秋季学術大会(第135回)
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞間相互作用によるAmelogenin H72、AmeloblastinおよびKLK4の誘導2011

    • Author(s)
      渡邉弘淳、下西充、高橋健、齊藤修、小松正志
    • Organizer
      日本歯科保存学会2011年度春季学術大会(第134回)
    • Place of Presentation
      千葉
    • Year and Date
      2011-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞間相互作用によるAmelogenin H72、AmeloblastinおよびKLK4の誘導2011

    • Author(s)
      渡邉弘淳、下西 充、高橋 健、齊藤 修、小松正志
    • Organizer
      日本歯科保存学会 2011年度 春季学術大会(第134回)
    • Place of Presentation
      浦安市
    • Related Report
      2011 Research-status Report
  • [Presentation] 培養ヒト歯根膜由来上皮細胞および線維芽細胞間相互作用による石灰化調整2011

    • Author(s)
      高橋 健、下西 充、渡邉弘淳、遠藤直樹、齊藤 修、小松正志
    • Organizer
      日本歯科保存学会 2011年度 秋季学術大会(第135回)
    • Place of Presentation
      大阪市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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