Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa
| Project/Area Number |
23592888
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
ATSUTA Ikiru 九州大学, 大学病院, 助教 (30423487)
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| Co-Investigator(Kenkyū-buntansha) |
古谷野 潔 九州大学, 歯学研究科(研究院), 教授 (50195872)
鮎川 保則 九州大学, 大学病院, 講師 (50304697)
鈴木 裕美子 九州大学, 歯学研究科(研究院), 研究員 (20432916)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | インプラント / 幹細胞 / 上皮封鎖 / 間葉系幹細胞 / インプラント周囲上皮 / インプラント周囲炎 / 細胞治療 / 国際研究者交流 / ニッチ / 生体材料（チタン） |
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| Research Abstract |
Mesenchymal stem cells (MSCs) are an attractive cell source in regenerative medicine because of their multi-differentiation capacity and regulatory functions, specifically at sites of inflammation. Here, we investigated the effect of systemic MSC transplantation on peri-implant epithelial sealing. MSCs were systemically injected into recipient rats via the tail vein. The injected MSCs accumulated at the injured gingival mucosa, following which the oral epithelium closed and peri-implant epithelium (PIE) formed from the oral sulcular epithelium earlier than in control rats. Furthermore, in the MSC-implant group, a laminin 332 (Ln)-positive layer was detected along the interface of the PIE-implant at 4 weeks. Conversely, Ln was only observed in the apical region and connective tissue region in the control group. Systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.
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Report
(4 results)
Research Products
(14 results)
