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Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa

Research Project

Project/Area Number 23592888
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKyushu University

Principal Investigator

ATSUTA Ikiru  九州大学, 大学病院, 助教 (30423487)

Co-Investigator(Kenkyū-buntansha) 古谷野 潔  九州大学, 歯学研究科(研究院), 教授 (50195872)
鮎川 保則  九州大学, 大学病院, 講師 (50304697)
鈴木 裕美子  九州大学, 歯学研究科(研究院), 研究員 (20432916)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsインプラント / 幹細胞 / 上皮封鎖 / 間葉系幹細胞 / インプラント周囲上皮 / インプラント周囲炎 / 細胞治療 / 国際研究者交流 / ニッチ / 生体材料(チタン)
Research Abstract

Mesenchymal stem cells (MSCs) are an attractive cell source in regenerative medicine because of their multi-differentiation capacity and regulatory functions, specifically at sites of inflammation. Here, we investigated the effect of systemic MSC transplantation on peri-implant epithelial sealing. MSCs were systemically injected into recipient rats via the tail vein. The injected MSCs accumulated at the injured gingival mucosa, following which the oral epithelium closed and peri-implant epithelium (PIE) formed from the oral sulcular epithelium earlier than in control rats. Furthermore, in the MSC-implant group, a laminin 332 (Ln)-positive layer was detected along the interface of the PIE-implant at 4 weeks. Conversely, Ln was only observed in the apical region and connective tissue region in the control group. Systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (6 results) (of which Invited: 2 results)

  • [Journal Article] In vivo and in vitro studies of epithelial cell behavior around titanium implants with machined- and rough-surface2013

    • Author(s)
      Atsuta I, Ayukawa Y, Furuhashi A, Ogino Y, Moriyama Y, Tsukiyama Y, Koyano K.
    • Journal Title

      Clinical Implant Dentistry and Related Research

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of Integrin beta-4 and alpha-3 subunits on the process of peri-implant epithelium formation2013

    • Author(s)
      Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Kondo R, Moriyama Y, Tsukiyama Y, Koyano K.
    • Journal Title

      Key Engineering Materials

      Volume: Vols.529-530

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mesenchymal stem cells inhibit multiple myeloma cells via the Fas-L/Fas pathway.2013

    • Author(s)
      Atsuta I, Liu S, Miura Y, Akiyama K, Chen C, An Y, Shi S, Chen FM.
    • Journal Title

      Stem Cell Res Ther

      Volume: 4(5) Pages: 111-111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17-mediated M1/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws.2013

    • Author(s)
      Zhang Q, Atsuta I, Liu S, Chen C, Shi S, Shi S, Le AD.
    • Journal Title

      Clin Cancer Res.

      Volume: 19(12) Pages: 3176-3188

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium.2013

    • Author(s)
      Atsuta I, Ayukawa Y, Furuhashi A, Yamaza T, Koyano K.
    • Journal Title

      Arch Oral Biol

      Volume: 58(11) Pages: 1696-1708

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cells in dentistry - Part II : Clinical applications2012

    • Author(s)
      Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K.
    • Journal Title

      J Prosthodont Res

      Volume: 56(4) Pages: 229-248

    • NAID

      130004546661

    • Related Report
      2013 Final Research Report
  • [Journal Article] Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw2012

    • Author(s)
      Zhao Y, Wang L, Liu Y, Akiyama K, Chen C, Atsuta I, Zhou T, Duan X, Jin Y, Shi S.
    • Journal Title

      Calcif Tissue Int

      Volume: 91(6) Pages: 400-408

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stem cells in dentistry--part I : stem cell sources2012

    • Author(s)
      Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K.
    • Journal Title

      J Prosthodont Res

      Volume: 56(3) Pages: 151-165

    • NAID

      130004546652

    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of Integrin beta-4 and alpha-3 subunits on the process of peri-implant epithelium formation2012

    • Author(s)
      Atsuta I, Ayukawa Y, Yamaza T, Furuhashi A, Kondo R, Moriyama Y, Tsukiyama Y, Koyano K.
    • Organizer
      Bioceramics 24
    • Place of Presentation
      Fukuoka
    • Related Report
      2013 Final Research Report
  • [Presentation] インシュリン様成長因子-Iを用いたインプラント周囲における上皮封鎖性の向上2012

    • Author(s)
      熱田生, 鮎川保則, 古橋明大, 古谷野潔
    • Organizer
      第42回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] インプラント表面性状の違いがラット口腔粘膜上皮に与える影響2012

    • Author(s)
      熱田生, 鮎川保則, 古橋明大, 荻野洋一郎, 森山泰子, 築山能大, 古谷野潔
    • Organizer
      社団法人日本補綴歯科学会第121回学術大会
    • Place of Presentation
      横浜(一般口演)
    • Related Report
      2013 Final Research Report
  • [Presentation] インプラント周囲上皮封鎖性の向上を目指した間葉系幹細胞治療

    • Author(s)
      熱田 生
    • Organizer
      公益社団法人日本補綴歯科学会 第122回学術大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] インプラント周囲における上皮封鎖性のしくみについて.

    • Author(s)
      熱田 生
    • Organizer
      第56回春季日本歯周病学会学術大会
    • Place of Presentation
      船越
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Injection timing of Mesenchymal Stem Cells to promote the soft tissue sealing around titanium implant.

    • Author(s)
      Atsuta I, Ayukawa Y, Kondo R, Furuhashi A, Matsuura Y, TsukiyamaY, Koyano K.
    • Organizer
      Biennial Joint Congress of CPS-JPS-KAP
    • Place of Presentation
      Cheju
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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