Development of resin contained Ag-doped bioglass that inhibit MMP activity of dentin
| Project/Area Number |
23592894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Kazuhiko 北海道医療大学, 歯学部, 教授 (70168821)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | MMP / バイオガラス / 劣化 / レジン接着 / ＭＭＰ / レジン系修復材料 / 接着耐久性 / 銀 / 細胞毒性 / 石灰化 / 象牙質 / レジン |
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| Research Abstract |
We evaluated the effects of a Ag-doped bioglass on inhibition of MMP and cytotoxicity to cells (RAW264). Ag-doped bioglass with 3% Ag2O inhibited the activity of MMP-2 and MMP-9 derived from dentin. However, this bioglass also showed cytotoxic effects. These findings may be attributed to the release of ions from bioglass. Further studies are required to optimize the bioglass composition for controlled release of ions to increase the inhibition effect of MMP activity and decrease the cytotoxicity.
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Report
(4 results)
Research Products
(41 results)
