| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
An aim of this study is to elucidate how bone marrow-derived mesenchymal stem cells (BM-MSCs) home and mobilize into oral and maxillofacial tissues at molecular level. We succeeded in establishment of in vitro culture system optimized for proliferation of BM-MSCs. Then, we tried to detect in vivo kinetics of transplanted BM-MSCs by tracing excited red fluorescence. Then, we succeeded in real time imaging of transplanted BM-MSCs by using IVIS. We are investigating molecular mechanisms underlying how transplanted BM-MSCs home and mobilize into specific tissues by collecting and investigating fluorescent cells from the histological sections.
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