Elucidation of molecular mechanisms underlying homing and mobilization of bone marrow-derived mesenchymal stem cells into oral and maxillofacial tissues
| Project/Area Number |
23592896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Hisatomo 岩手医科大学, 歯学部, 教授 (70343150)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTSUKA Masato 東海大学, 医学部, 講師 (90372945)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / ホーミング / 蛍光トレース / 増殖 / 分化 / 前駆細胞 / tdTomato / 臓器幹細胞 |
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| Research Abstract |
An aim of this study is to elucidate how bone marrow-derived mesenchymal stem cells (BM-MSCs) home and mobilize into oral and maxillofacial tissues at molecular level. We succeeded in establishment of in vitro culture system optimized for proliferation of BM-MSCs. Then, we tried to detect in vivo kinetics of transplanted BM-MSCs by tracing excited red fluorescence. Then, we succeeded in real time imaging of transplanted BM-MSCs by using IVIS. We are investigating molecular mechanisms underlying how transplanted BM-MSCs home and mobilize into specific tissues by collecting and investigating fluorescent cells from the histological sections.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells2014
Author(s)
Aomatsu E, Takahashi N, Sawada S, Okubo N, Hasegawa T, Taira M, Miura H, Ishisaki A, Chosa N.
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Journal Title
Scientific Reports
Volume: Jan 13, 4
Pages: 3652-3652
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] EGF positively regulates the proliferation and migration, and negatively regulates the myofibroblast differentiation of periodontal ligament-derived endothelial progenitor cells through MEK/ERK- and JNK-dependent signals.2013
Author(s)
Kimura, H., Okubo, N., Chosa, N., Kyakumoto, S., Kamo, M., Miura, H. and Ishisaki, A
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Journal Title
Cellular Physiology and Biochemistry
Volume: 32
Pages: 899-914
DOI
Related Report
Peer Reviewed
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