The gene regulatory network relating to the differentiation of dental pulp stem cells into odontoblasts
| Project/Area Number |
23592903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
TAKEKI Tsutsui 日本歯科大学, 生命歯学部, 教授 (00097065)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tomoko 日本歯科大学, 生命歯学部, 助教 (10548283)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒト歯髄幹細胞 / 多分化能 / DNAマイクロアレイ / 石灰化能 / 脂肪分化能 |
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| Research Abstract |
Using cell clones derived from the human dental pulp tissue, we studied genes involved in the differentiation of dental pulp stem cells by analyzing cell growth, differentiation potentials, and gene expression profiles. Some genes involved in signal networks (such as Wnt and Notch signaling pathways) and some gene clusters (such as carbohydrate metabolism-, cell cycle- and differentiation-relating genes) turned out up- or down-regulated in the differentiation process. To elucidate the function of sex hormone receptors on dental pulp cells, the gene expression profiles of the dental pulp cells treated with sex hormones were analyzed. We found that sex hormones could act directly on human dental pulp cells through sex hormone receptors.
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Report
(4 results)
Research Products
(10 results)
