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Elucidation of the mechanism of action in salivary protein histatin aimed at soft tissue injury treatment and regenerative medicine

Research Project

Project/Area Number 23592906
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

IMAMURA Yasuhiro  松本歯科大学, 歯学部, 講師 (00339136)

Co-Investigator(Kenkyū-buntansha) YUKITA Akira  静岡大学, 教育学部, 講師 (80401214)
FUJINAMI Yoshiaki  松本歯科大学, 歯学部, 助手 (80392801)
TAKAHASHI Naoyuki  松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
Co-Investigator(Renkei-kenkyūsha) WANG Pao-li  大阪歯科大学, 歯学部, 教授 (20213613)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords唾液蛋白質 / ヒスタチン
Research Abstract

Salivary protein histatins have antimicrobial properties and protect oral tissues from pathogens (e.g., periodontal pathogens and Candida albicans). However, very little is known about the function of histatins against host cells. In this study, we showed a part of mechanism enhancing cell proliferation by histatin in human gingival fibroblasts. It has also been suggested the possibility that histatin is concerned with other cell cycle regulatory functions. In addition, we showed the mechanism of anti-inflammatory action by histatin. These observations are advocated as new physiological function of salivary protein. These results are connected with regenerative medicine (and tissue engineering) and with development of anti-inflammatory agent.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results)

  • [Journal Article] Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts2014

    • Author(s)
      Imamura, Y. and Wang, P.-L.
    • Journal Title

      J. Inflamm.

      Volume: Vol.11 Pages: 4-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts2014

    • Author(s)
      Yasuhiro Imamura, Pao-Li Wang
    • Journal Title

      Journal of Inflammation

      Volume: 11 Issue: 1 Pages: 4-4

    • DOI

      10.1186/1476-9255-11-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel single nucleotide polymorphism of the interleukin-8 promoter: its transcriptional regulation and analysis of the mutation in periodontal disease in the Japanese population2012

    • Author(s)
      Imamura, Y.
    • Journal Title

      J. Hard Tissue Biol.

      Volume: 21 Pages: 427-434

    • NAID

      130004848389

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 唾液ヒスタチンによる熱ショック蛋白質のToll様受容体リガンド効果抑制機序2013

    • Author(s)
      今村泰弘
    • Organizer
      第55回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      岡山県岡山市岡山コンベンションセンター
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液タンパク質ヒスタチンによる細胞周期制御機構(Cell cycle control mechanisms by salivary protein histatin)2012

    • Author(s)
      今村泰弘
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡県福岡市福岡国際会議場・マリンメッセ福岡
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 熱ショック蛋白質による炎症性サイトカイン産生に対するヒスタチンとその変異体の影響2012

    • Author(s)
      今村泰弘
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      福島県郡山市奥羽大学
    • Year and Date
      2012-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液ヒスタチンによる熱ショック蛋白質のTLR2シグナル活性化抑制2011

    • Author(s)
      今村泰弘
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      岐阜県岐阜市長良川国際会議場
    • Year and Date
      2011-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 唾液ヒスタチンによる熱ショック蛋白質のTLR2シグナル活性化抑制2011

    • Author(s)
      今村 泰弘
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 唾液ヒスタチンによる熱ショック蛋白質のToll 様受容体リガンド効果抑制機序

    • Author(s)
      今村泰弘、王宝禮
    • Organizer
      第55回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳歯列期重度齲蝕症とβ-ディフェンシン1遺伝子の一塩基多型解析

    • Author(s)
      青木 伯永
    • Organizer
      第50回日本小児歯科学会大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 熱ショック蛋白質による炎症性サイトカイン産生に対するヒスタチンとその変異体の影響

    • Author(s)
      今村 泰弘
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Related Report
      2012 Research-status Report
  • [Presentation] オゾンジェルの歯周病関連細菌への影響

    • Author(s)
      王 宝禮
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 乳歯列期重度齲蝕症におけるDEFB1の遺伝子型解析

    • Author(s)
      青木 伯永
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 唾液タンパク質ヒスタチンによる細胞周期制御機構(Cell cycle control mechanisms by salivary protein histatin)

    • Author(s)
      今村 泰弘
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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