| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Inside the coral were innumerable tubular structures 100-300 μm in diameter that communicated with the outside, connected to neighboring ducts through pores. The surface of the skeleton was covered with 10-20 μm protrusions, on the surface of which further rounded projections of 6-200 nm were observed. The calcium of coral was released in acid solution, and calcium irons in the alkaline solution were deposited on the surface coral particles. In vitro, formation of capillaries was seen around coral particles. In vivo, at bone defects of dogs and on the skull of rats, multinucleated giant cells were observed in contact with the implanted coral, and bone augmentation was seen together with newly formed bone bordered by osteoblasts in the inner cavities of the coral block. After 12 months, coral block were disappeared and replaced with newly formed bone and bone marrow.
The above suggests that coral blocks are promising as a bioabsorpable scaffolding material for bone augmentation.
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