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Development of the new BRONJ cure targeted immunocompetent cells

Research Project

Project/Area Number 23592910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

TEI Kanchu  北海道大学, 歯学研究科(研究院), 教授 (80180066)

Co-Investigator(Kenkyū-buntansha) YOSHIMURA Yoshitaka  北海道大学, 大学院歯学研究科, 助教 (30230816)
KIKUIRI Takashi  北海道大学, 大学院歯学研究科, 助教 (10322819)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯学 / 顎骨壊死 / ビスフォスフォネート製剤 / ビスフォスフォネート
Research Abstract

Bisphosphonates-related osteonecrosis of the jaw (BRONJ) is a refractory disease that is osteonecrosis of the jaw in a patient who was receiving or had been exposed to bisphosphonate therapy. Here we conducted to consider whether it is possible to prevent BRONJ by anti-inflammatory drugs and elucidation of the pathogenesis of BRONJ. It was suggested that BRONJ occurred because of failure of the balance of immunity and the excessive inflammatory reaction by the analysis of the BRONJ model mouse. In addition, by the anti-inflammatory drugs, BRONJ was reduced. These results suggested that the anti-inflammatory drugs might prevent BRONJ or reduce a BRONJ symptom.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells2012

    • Author(s)
      Abe K, Yoshimura Y, Deyama Y, et al
    • Journal Title

      International Journal of Molecular Medicine

      Volume: 29 Pages: 1007-1015

    • DOI

      10.3892/ijmm.2012.952

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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