Establishment of in situ bone regenerative technology to induce mature cortical bone formation containing osteons
| Project/Area Number |
23592913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANNNO Yuki 東京大学, 医学部附属病院, 助教 (80451813)
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| Co-Investigator(Kenkyū-buntansha) |
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
HOSHI Kazuto 東京大学, 医学部附属病院, 准教授 (30344451)
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
KIKUCHI Masanori 独立行政法人, 物質材料機構, リーダー (00354267)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | オステオン / 皮質骨誘導型人工骨 / 成長因子 / サイトカイン / in situ骨再生技術 / 吸収性メッシュトレー / 下顎骨欠損モデル / 骨形成 / 再生医学 / 細胞・組織 / 歯学 / 骨再生 / 骨皮質 |
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| Research Abstract |
The purpose of this study is to clarify the mechanism of osteons formation and regeneration that has never been studied and in vivo osteons formation and regeneration mechanism using novel biomaterials technologies. Therefore, we establish the in situ bone regeneration techniques to induce maturation bone matrix formation that was difficult until now. Thus, we examined the utility of cortical bone induced artificial bone with the addition of growth factors or cytokines by using the experimental dog (Beagle) model which found osteons structure in the same as human.
Furthermore, we prepared in situ regenerative bone tissue, which placed in a new absorbable mesh tray cortical bone induced artificial bone, and implanted in beagle bone defect model to verify their usefulness.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Hollow Fiber Module Applied for Effective Proliferation and Harvest of Cultured Chondrocytes2013
Author(s)
Mori Y, Watanabe M, Nakagawa S, Asawa Y, Nishizawa S, Okubo K, Saijo H, Nagata S, Fujihara Y, Takato T, Hoshi K.
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Journal Title
Materials Sci and Applications
Volume: 4
Pages: 62-67
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[Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling.2013
Author(s)
Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, and Hoshi K
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Journal Title
J Cell Physiol
Volume: (in press)
Issue: 1
Pages: 163-71
DOI
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Peer Reviewed
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[Journal Article] Recent trends of cartilage regenerative medicine and its application to the oral and maxillofacial surgery
Author(s)
Hoshi K, Fujihara Y, Asawa Y, Nishizawa S, Kanazawa S, Sakamoto T, Watanabe M, Ogasawara T, H S, Mori Y, Takato T.
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Journal Title
Oral Sci Int
Volume: (in press)
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[Presentation] 片側性唇顎口蓋裂患者に対し, チタンメッシュを併用し, インプラント治療を行った1例2011
Author(s)
菅野勇樹, 西條英人, 斎藤健太郎, 古賀陽子, 杉山円, 安部貴大, 瀬戸一郎, 森良之, 高戸毅
Organizer
第15回日本顎顔面インプラント学会総会・学術大会
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