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Possibility of limited resection following preoperative therapy for squamous cell carcinoma of the tongue based on real-time tissue elastography

Research Project

Project/Area Number 23592914
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

HARADA Hiroyuki  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (40343149)

Co-Investigator(Renkei-kenkyūsha) OMURA Ken  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10334434)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords舌扁平上皮癌 / 組織弾性イメージング / 縮小手術 / 術前治療
Research Abstract

Preservation of function is an important issue in the treatment of oral cancers. With recent advances in anticancer agents and radiation therapy, many patients are known to obtain a high antitumor effect. Using real-time tissue elastography, the elasticity of squamous cell carcinoma of the tongue was measured, and the elasticity of scar portions was quantified in cases when preoperative therapy was performed.
This result was as expected and is a finding that shows that the portion of cancer tissue lost with preoperative therapy had lower elasticity than cancer and higher elasticity than normal tissue. If a cutoff value for tumor tissue and scar tissue can be established in the future, the possibility of limited surgery can probably be expanded.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (12 results)

  • [Journal Article] Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma2013

    • Author(s)
      Harada H, Omura K, Tomioka H, Nakayama H, Hiraki A, Shinohara M, Yoshihama Y, Shintani S.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71(4) Pages: 1059-1064

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cervical lymph node metastasis from early-stage squamous cell carcinoma of the oral tongue2013

    • Author(s)
      Yuasa-Nakagawa K, Shibuya H, Yoshimura R, Miura M, Watanabe H, Kishimoto S, Omura K.
    • Journal Title

      Acta Otolaryngol

      Volume: 133(5) Pages: 544-551

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma.2013

    • Author(s)
      Harada H, Omura K, Tomioka H, Nakayama H, Hiraki A, Shinohara M, Yoshihama Y, Shintani S
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 4 Pages: 1059-1064

    • DOI

      10.1007/s00280-013-2101-5

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cervical lymph node metastasis from early-stage squamous cell carcinoma of the oral tongue2013

    • Author(s)
      Yuasa-Nakagawa K, Shibuya H, Yoshimura R, Miura M, Watanabe H, Kishimoto S, Omura K
    • Journal Title

      Acta Otolaryngol

      Volume: 133 Issue: 5 Pages: 544-51

    • DOI

      10.3109/00016489.2012.748988

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of metastatic cervical lymph nodes in patients with oral squamous cell carcinoma using 18F-FDG PET-CT scans and histopathologic correlation2012

    • Author(s)
      Mochizuki Y, Omura K, Nakamura S, Kayamori K, Harada H, Shibuya H.
    • Journal Title

      J Surg Rad

      Volume: 3(4) Pages: 210-215

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative predictive model of cervical lymph node metastasis combining fluorine-18 fluorodeoxyglucose positron-emission tomography/computerized tomography findings and clinical factors in patients with oral or oropharyngeal squamous cell carcinoma2012

    • Author(s)
      Mochizuki Y, Omura K, Nakamura S, Harada H, Shibuya H, Kurabayashi T.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 113(2) Pages: 274-282

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cementoblastoma arising in the maxilla of an 8-year-old boy : a case report2011

    • Author(s)
      Harada H, Omura K, Mogi S, Okada N.
    • Journal Title

      Int J Dent

      Volume: 2011 Pages: 384578-384578

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 当科受診前に外科処置が行われた歯肉癌症例の検討2011

    • Author(s)
      富岡寛文, 小村健, 原田浩之, 生田稔
    • Journal Title

      頭頸部癌

      Volume: 37(1) Pages: 18-23

    • NAID

      10030814727

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム「口腔外科治療の最前線」口底扁平上皮癌の臨床病理学的検討2013

    • Author(s)
      原田浩之, 小村健, 島本裕彰
    • Organizer
      第51回日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔扁平上皮癌における選択的頸部郭清術2013

    • Author(s)
      原田浩之, 小村健, 島本裕彰
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinico-pathological study on occult cervical lymph node metastasis in oral tongue carcinoma2013

    • Author(s)
      Harada H, Omura K, Nakajima Y, Shimamoto H, Tomioka H, Tanaka K, Hirai H.
    • Organizer
      4th World Congress of the International Academy of Oral Oncology
    • Place of Presentation
      Rohdes Island, Greece
    • Related Report
      2013 Final Research Report
  • [Presentation] Bone invasion relate to cervical lymph node metastasis in squamous cell carcinoma of lower gingiva2013

    • Author(s)
      Tomioka H, Omura K, Kugimoto T, Hirai H, Mochizuki Y, Tanaka K, Shimamoto H, Nakajima Y, Harada H.
    • Organizer
      4th World Congress of the International Academy of Oral Oncology
    • Place of Presentation
      Rohdes Island, Greece
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 口底扁平上皮癌の臨床病理学的検討.2013

    • Author(s)
      原田浩之, 小村 健, 島本裕彰
    • Organizer
      第51回日本癌治療学会総会シンポジウム『口腔外科治療の最前線』
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔扁平上皮癌における選択的頸部郭清術2013

    • Author(s)
      原田浩之, 小村 健, 島本裕彰
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      新宿
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinico-pathological study on occult cervical lymph node metastasis in oral tongue carcinoma.2013

    • Author(s)
      Harada H, Omura K, Nakajima Y, Shimamoto H, Tomioka H, Tanaka K, Hirai H
    • Organizer
      4th World Congress of the International Academy of Oral Oncology
    • Place of Presentation
      Rohdes Island, Greece
    • Related Report
      2013 Annual Research Report
  • [Presentation] 舌扁平上皮癌N0症例の頸部後発転移に関する臨床病理学的検討2012

    • Author(s)
      原田浩之, 小村健, 中島雄介, 島本裕彰, 富岡寛文, 田中香衣, 釘本琢磨, 大迫利光
    • Organizer
      第57回日本口腔外科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] 口底扁平上皮癌における原発巣再発の臨床的検討2012

    • Author(s)
      原田浩之, 小村健, 中島雄介, 島本裕彰, 富岡寛文, 田中香衣, 釘本琢磨, 大迫利光
    • Organizer
      第36回日本頭頸部癌学会
    • Place of Presentation
      松江市
    • Related Report
      2013 Final Research Report
  • [Presentation] 口底扁平上皮癌の臨床病理学的検討2011

    • Author(s)
      原田浩之, 小村健, 中島雄介,生田稔, 島本裕彰, 富岡寛文, 田中香衣, 金親あや乃, 釘本琢磨, 大迫利光
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔扁平上皮癌における術前TS-1・放射線同時併用療法の臨床第II相試験2011

    • Author(s)
      原田浩之, 小村健, 中山秀樹, 平木昭光, 篠原正徳, 吉濱泰斗
    • Organizer
      第29回日本口腔腫瘍学会総会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔扁平上皮がん頸部リンパ節転移の術前診断における18FDG-PETの有用性の検討2011

    • Author(s)
      望月裕美, 中村伸, 小村健, 原田浩之, 中島雄介, 生田稔, 島本裕彰, 森田圭一, 富岡寛文,田中香衣,金親あや乃, 渋谷均
    • Organizer
      第29回日本口腔腫瘍学会総会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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