| Project/Area Number |
23592914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HARADA Hiroyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (40343149)
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| Co-Investigator(Renkei-kenkyūsha) |
OMURA Ken 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10334434)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 舌扁平上皮癌 / 組織弾性イメージング / 縮小手術 / 術前治療 |
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| Research Abstract |
Preservation of function is an important issue in the treatment of oral cancers. With recent advances in anticancer agents and radiation therapy, many patients are known to obtain a high antitumor effect. Using real-time tissue elastography, the elasticity of squamous cell carcinoma of the tongue was measured, and the elasticity of scar portions was quantified in cases when preoperative therapy was performed.
This result was as expected and is a finding that shows that the portion of cancer tissue lost with preoperative therapy had lower elasticity than cancer and higher elasticity than normal tissue. If a cutoff value for tumor tissue and scar tissue can be established in the future, the possibility of limited surgery can probably be expanded.
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